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At-home spit test better than blood test at detecting prostate cancer

Spit test beats PSA? New study shows saliva-based DNA test may better predict prostate cancer risk in men.

A simple at-home spit test may be more accurate at detecting prostate cancer than the current prostate-specific antigen (PSA) blood test, new NIHR-funded research suggests. This new method could better identify the future risk of cancer for some men. The BARCODE 1 study calculated the risk of prostate cancer from DNA extracted from saliva. This is called a polygenic risk score (PRS). The study was partly funded by the NIHR Royal Marsden Biomedical Research Centre. It was supported by NIHR Research Delivery Network and published in the New England Journal of Medicine.

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NeoHealth® ID 37892 · updated 5/29/2025