Articles
Depression unveiled: a comprehensive review of pathophysiology and treatment advances
Clinically, depression manifests through symptoms such as feelings of worthlessness, cognitive and sleep disturbances, and suicidal ideation, with major depression representing the predominant subtype.
Depression, affecting over 300 million people, is a major global health challenge. Its complex pathogenesis involves genetic, neurotransmitter, and HPA-axis dysfunction. While both pharmacological and non-pharmacological interventions exist, antidepressant medications are the cornerstone of treatment. Untreated depression can lead to widespread complications and severely impact a person's quality of life.
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