Articles
Effectiveness of islatravir post-exposure prophylaxis after intravenous challenge with simian immunodeficiency virus in rhesus macaques
A study on rhesus macaques found that islatravir (ISL), an NRTTI, effectively prevented SIV infection when given 24 hours after exposure. Two weekly doses provided complete protection, suggesting its potential as a long-acting oral post-exposure prophylaxis (PEP) for HIV, warranting further research.
Islatravir (ISL) is a nucleoside reverse transcriptase translocation inhibitor (NRTTI) with robust antiretroviral activity. The efficacy of ISL administered for post-exposure prophylaxis (PEP) was evaluated in a simian immunodeficiency virus (SIV) rhesus macaque intravenous (IV) challenge model.
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