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Personalized High-Definition Transcranial Direct Current Stimulation for the Treatment of Depression

Is high-definition transcranial direct current stimulation a viable treatment for major depression?

A trial on high-definition transcranial direct current stimulation (HD-tDCS) for moderate to severe depression found that active treatment for 12 days led to a significant improvement in mood compared to a sham group. HD-tDCS was well-tolerated and showed a moderate effect size. The findings suggest it could be an effective and fast-acting alternative to traditional depression treatments.

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NeoHealth® ID 38481 · updated 9/17/2025