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Popular artificial sweetener may negatively affect cancer immunotherapy

Non-sugar, or artificial, sweeteners are widely used to reduce the energy in sweetened foods and drinks, particularly those marketed as diet, or low or no sugar.

A new study found that the artificial sweetener sucralose can adversely affect cancer immunotherapy by altering the gut microbiome. Researchers suggest that sucralose-driven changes cause bacteria to degrade the amino acid arginine, which is essential for immune cells to fight cancer. This could lead to a poorer response to treatment in patients with a high intake of the sweetener.

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NeoHealth® ID 38423 · updated 9/1/2025