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SAHPRA clarifies the benefits and risks of medroxyprogesterone acetate

SAHPRA Issues Warning: Medroxyprogesterone Acetate (MPA) Products to Include Meningioma Risk—What You Need to Know!

The South African Health Products Regulatory Authority (SAHPRA) has recommended that the product information of medroxyprogesterone acetate (MPA)-containing products be amended by updating the safety warnings to include the potential risk of meningioma.

MPA is a synthetic oral and injectable form of the hormone progesterone and is used for contraception and the management of endometriosis-associated pain. It is also indicated in the palliative treatment of recurrent and/or metastatic endometrial cancer, renal cancer and breast cancer in postmenopausal women.

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NeoHealth® ID 37469 · updated 5/29/2025