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Systematic review and meta-analysis of the non-specific and broader impact of respiratory vaccines on acute lower respiratory infections in young children

Growing evidence suggests that vaccines targeting respiratory pathogens have non-specific and broader effects.

This review demonstrated both protective and neutral non-specific effects of respiratory vaccines against ALRI-hospitalisations and related outcomes in young children. Such effects should be considered as part of the full value of a vaccine and how vaccine investments are prioritised.

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NeoHealth® ID 38842 · updated 12/12/2025