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WHO releases updated recommendations on HIV clinical management

The WHO has released updated recommendations on HIV clinical management, providing new and revised guidance on antiretroviral therapy, management of vertical HIV transmission, and tuberculosis (TB) prevention for people living with HIV.

The updated recommendations confirm dolutegravir-based regimens as the preferred option for initial and subsequent HIV treatment and introduce important changes for people whose treatment regimen is no longer effective. When a protease inhibitor (PI) is needed, darunavir/ritonavir is now recommended as the preferred option, replacing earlier preferences for atazanavir/ritonavir or lopinavir/ritonavir. 

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NeoHealth® ID 38917 · updated 1/21/2026