neobookRx
DrugsLevel 4 LocalisationS2EFTEML

A.B.O.B/ Phenylephrine/ Chlorphenamine/ Aspirin/ Ascorbic Acid

CombinationDecongestant, Antihistamine, Anti-inflammatory, Analgesic

Indications

Registered South African indications:

  • Rhinitis, laryngitis and muscular pains
  • Distressing symptoms of colds and influenza

Boxed warning

Aspirin has been implicated in Reye's syndrome, a rare but serious illness, in children and teenagers with chickenpox and influenza. A doctor should be consulted before aspirin is used in such patients

Contraindications (ZA)

Registered South African contraindications

  • Hypersensitivity to the active ingredients or any of the excipients in this combination product
  • Dyspepsia
  • Lesions of the gastric mucosa
  • Renal dysfunction
  • Severe hyperthyroidism (use with caution)
  • High blood pressure (use with caution)
  • Heart conditions (use with caution)
  • Aspirin allergy

Warnings & precautions

South African recommendations

  • Pregnancy
  • Breastfeeding
  • Hepatic impairment
  • Elderly
  • Use in children and adolescents with chickenpox and influenza

Adult dosage (ZA)

Forms avail. in SA and covered in this monograph: eft

South African registered indications and dosages

Rhinitis, laryngitis and muscular pains
Distressing symptoms of colds and influenza
- For quick relief

A.B.O.B HCl/ Phenylephrine HCl/ Chlorphenamine/ Aspirin/ Ascorbic Acid
100/7.5/2/500/500 (mg)

  • Oral (eft): 2 tab, immediately; Then 1 tab, 3-4 times a day as required

Drop the tablet in half a glass of cold water. The tablet quickly dissolves producing a refreshing effervescent drink. Drink the mixture as soon as the effervescing has stopped


Usage beyond 10 days without consulting a doctor is not recommended

Paediatric dosage (ZA)

Paed. forms avail. in SA and covered in this monograph: eft

South African registered indications and dosages

Rhinitis, laryngitis and muscular pains
Distressing symptoms of colds and influenza
- For quick relief

A.B.O.B HCl/ Phenylephrine HCl/ Chlorphenamine/ Aspirin/ Ascorbic Acid
100/7.5/2/500/500 (mg)

  • Younger than 6 years: No information available
  • Older than 6 years: Oral (eft): Half a tab, 3-4 times a day 

Drop the tablet in half a glass of cold water. The tablet quickly dissolves producing a refreshing effervescent drink. Drink the mixture as soon as the effervescing has stopped


Usage beyond 10 days without consulting a doctor is not recommended

Pregnancy & lactation

South African recommendations

  • Caution; no information available

Renal impairment

South African recommendations

  • Contraindicated

Hepatic impairment

South African recommendations

  • Caution; no information available

Elderly

South African recommendations

  • Caution; no information available

Adverse reactions

Central Nervous System Disorders

  • Drowsiness
  • Impaired concentration

Interactions

  • Other central nervous system depressants
  • Alcohol

Monitoring

None routine

Mechanism of action

The combined therapeutic effect of acetylsalicylic acid (aspirin) plus the antihistamines and decongestants has been well established as effective treatment for the relief of influenza symptoms. Vitamin C (ascorbic acid) has been claimed to be an essential factor in building up the patients’ resistance to infections as well as speeding their recovery rate. A.B.O.B. HCl has an anti-viral activity.

Dosage forms

  • Effervescent tablet

Formulation

COMBINATION PREPARATIONS

Aspirin/ Ascorbic acid/ ABOB/ Phenylephrine/ Chlorpheniramine

Tablet effervescent 500mg/500mg/100mg/7.5mg/2mg

  • Corenza C (Adcock)

References

1. PI - CORENZA-C® (EFFERVESCENT TABLET), Adcock Ingram Limited - DATE OF PUBLICATION OF THIS PACKAGE INSERT: 18 September 1970 Downloaded online 14 September 2023 [https://medsinfoportal.sahpra.org.za/pi/edd8e5b7ca884541b70f5922414e6146.pdf] 2. South African Institute for Drug-Free Sport: Corenza C; Downloaded online 14 September 2023 [http://www.drugfreesport.org.za/online-medication-check/] NAPOS not available for combination No SmPC available - checked 22 September 2023

Brands & products

2 products · cached snapshot
Trade names (1)
  • Chlorpheniramine maleate (syn. Chlorphenamine)Aspirin (syn. Acetylsalicylic acid)Corenza C

EFTEffervescent tablet · 2 products

from R78.44
ProductStrengthPackApplicantMin price
Corenza C100 mg;mg;mg;mg;mg10Adcock Ingram LimitedR78.44
Corenza C100 mg;mg;mg;mg;mg20Adcock Ingram LimitedR156.88

Medical aid coverage

data not yet integrated
Discovery Health
not yet integrated
  • Comprehensive Series—
  • Executive Plan—
  • KeyCare Series—
  • Priority Series—
  • Saver Series—

Formulary scraper pending — coverage tier, co-pay and authorisation requirements will appear here once data is ingested.

Bonitas Medical Fund
not yet integrated
  • BonClassic—
  • BonComprehensive—
  • BonEssential—
  • BonFit Select—
  • BonSave—
  • BonStart—

Formulary scraper pending — coverage tier, co-pay and authorisation requirements will appear here once data is ingested.

GEMS — Government Employees Medical Scheme
not yet integrated
  • Beryl—
  • Emerald—
  • Onyx—
  • Ruby—
  • Sapphire—
  • Tanzanite One—

Formulary scraper pending — coverage tier, co-pay and authorisation requirements will appear here once data is ingested.

POLMED — Police Medical Aid Scheme
not yet integrated
  • Aquarium Option—
  • Efficiency Option—
  • Marine Option—

Formulary scraper pending — coverage tier, co-pay and authorisation requirements will appear here once data is ingested.

NeoHealth® ID 15706 · updated 9/22/2023