A.B.O.B/ Phenylephrine/ Chlorphenamine/ Aspirin/ Ascorbic Acid
Indications
Registered South African indications:
- Rhinitis, laryngitis and muscular pains
- Distressing symptoms of colds and influenza
Boxed warning
| Aspirin has been implicated in Reye's syndrome, a rare but serious illness, in children and teenagers with chickenpox and influenza. A doctor should be consulted before aspirin is used in such patients |
Contraindications (ZA)
Registered South African contraindications
- Hypersensitivity to the active ingredients or any of the excipients in this combination product
- Dyspepsia
- Lesions of the gastric mucosa
- Renal dysfunction
- Severe hyperthyroidism (use with caution)
- High blood pressure (use with caution)
- Heart conditions (use with caution)
- Aspirin allergy
Warnings & precautions
South African recommendations
- Pregnancy
- Breastfeeding
- Hepatic impairment
- Elderly
- Use in children and adolescents with chickenpox and influenza
Adult dosage (ZA)
Forms avail. in SA and covered in this monograph: eft
South African registered indications and dosages
Rhinitis, laryngitis and muscular pains
Distressing symptoms of colds and influenza
- For quick relief
A.B.O.B HCl/ Phenylephrine HCl/ Chlorphenamine/ Aspirin/ Ascorbic Acid
100/7.5/2/500/500 (mg)
- Oral (eft): 2 tab, immediately; Then 1 tab, 3-4 times a day as required
Drop the tablet in half a glass of cold water. The tablet quickly dissolves producing a refreshing effervescent drink. Drink the mixture as soon as the effervescing has stopped
Usage beyond 10 days without consulting a doctor is not recommended
Paediatric dosage (ZA)
Paed. forms avail. in SA and covered in this monograph: eft
South African registered indications and dosages
Rhinitis, laryngitis and muscular pains
Distressing symptoms of colds and influenza
- For quick relief
A.B.O.B HCl/ Phenylephrine HCl/ Chlorphenamine/ Aspirin/ Ascorbic Acid
100/7.5/2/500/500 (mg)
- Younger than 6 years: No information available
- Older than 6 years: Oral (eft): Half a tab, 3-4 times a day
Drop the tablet in half a glass of cold water. The tablet quickly dissolves producing a refreshing effervescent drink. Drink the mixture as soon as the effervescing has stopped
Usage beyond 10 days without consulting a doctor is not recommended
Pregnancy & lactation
South African recommendations
- Caution; no information available
Renal impairment
South African recommendations
- Contraindicated
Hepatic impairment
South African recommendations
- Caution; no information available
Elderly
South African recommendations
- Caution; no information available
Adverse reactions
Central Nervous System Disorders
- Drowsiness
- Impaired concentration
Interactions
- Other central nervous system depressants
- Alcohol
Monitoring
None routine
Mechanism of action
The combined therapeutic effect of acetylsalicylic acid (aspirin) plus the antihistamines and decongestants has been well established as effective treatment for the relief of influenza symptoms. Vitamin C (ascorbic acid) has been claimed to be an essential factor in building up the patients’ resistance to infections as well as speeding their recovery rate. A.B.O.B. HCl has an anti-viral activity.
Dosage forms
- Effervescent tablet
Formulation
COMBINATION PREPARATIONS
Aspirin/ Ascorbic acid/ ABOB/ Phenylephrine/ Chlorpheniramine
Tablet effervescent 500mg/500mg/100mg/7.5mg/2mg
- Corenza C (Adcock)
References
1. PI - CORENZA-C® (EFFERVESCENT TABLET), Adcock Ingram Limited - DATE OF PUBLICATION OF THIS PACKAGE INSERT: 18 September 1970 Downloaded online 14 September 2023 [https://medsinfoportal.sahpra.org.za/pi/edd8e5b7ca884541b70f5922414e6146.pdf] 2. South African Institute for Drug-Free Sport: Corenza C; Downloaded online 14 September 2023 [http://www.drugfreesport.org.za/online-medication-check/] NAPOS not available for combination No SmPC available - checked 22 September 2023
Brands & products
2 products · cached snapshot- Chlorpheniramine maleate (syn. Chlorphenamine)Aspirin (syn. Acetylsalicylic acid)Corenza C
EFTEffervescent tablet · 2 products
from R78.44| Product | Strength | Pack | Applicant | Min price |
|---|---|---|---|---|
| Corenza C | 100 mg;mg;mg;mg;mg | 10 | Adcock Ingram Limited | R78.44 |
| Corenza C | 100 mg;mg;mg;mg;mg | 20 | Adcock Ingram Limited | R156.88 |
Medical aid coverage
data not yet integrated- Comprehensive Series—
- Executive Plan—
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- Beryl—
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- Tanzanite One—
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- Aquarium Option—
- Efficiency Option—
- Marine Option—
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