Ammonium Chloride/ Sorbimacrogol

Registered South African indications:

• Alleviation of cough

Registered South African contraindications

• Hypersensitivity to the active ingredient or any of the excipients in this combination product
• Impaired renal function
• Impaired hepatic function

South African recommendations

• Pregnancy
• Breastfeeding
• Elderly

Sucrose content

• Not suitable for patients with rare hereditary conditions such as fructose intolerance, glucose-galactose malabsorption, or sucrase-isomaltase insufficiency

Effects on ability to drive and use machines

• Exercise caution when operating machinery or driving after taking the medicine

Interactions

• Sorbimacrogol laurate 300 may increase the absorption of liquid paraffin and other fat-soluble substances

Forms avail. in SA and covered in this monograph: syr 

South African registered indications and dosages

Alleviation of cough

Ammonium Chloride/ Sorbimacrogol
34/36.33 (mg/10ml)

• Oral (syr): 5-10ml, 3-6 times a day

Syrup should be kept in the mouth for a few minutes

Should not be administered together with food or beverages

Paed. forms avail. in SA and covered in this monograph: syr 

South African registered indications and dosages

Alleviation of cough

Ammonium Chloride/ Sorbimacrogol
34/36.33 (mg/10ml)

• Younger than 3 years: Not established for use
• Older than 3 years: Oral (syr): 5ml, 3-6 times a day

Syrup should be kept in the mouth for a few minutes

Should not be administered together with food or beverages

Pregnancy 

South African recommendations

• Caution
• The safety of this medicine in pregnancy has not been established

Breastfeeding

South African recommendations

• Caution
• The safety of this medicine in lactation has not been established

Fertility

South African recommendations

• No information available

South African recommendations

• Contraindicated
  Ammonium chloride/ sorbimacrogol syrup is contraindicated in the presence of impaired renal function

South African recommendations

• Contraindicated
  Ammonium chloride/ sorbimacrogol syrup is contraindicated in the presence of impaired hepatic function

South African recommendations

• Caution; no information available

Combination products may have additional pharmacological effects not accounted for by the action of the individual ingredients

Ammonium Chloride

Gastrointestinal Disorders

• Nausea
• Vomiting

Nervous System Disorders

• Headache
• Progressive drowsiness

Metabolism and Nutrition Disorders

• Acidosis
• Hypokalaemia

Respiratory, Thoracic and Mediastinal Disorders

• Hyperventilation

General Disorders and Administration Site Conditions

• Thirst

Sorbimacrogol

• No information available

Combination products may have additional pharmacological effects not accounted for by the action of the individual ingredients

Ammonium Chloride

• No information available

Sorbimacrogol

• Liquid paraffin
• Other fat soluble substances

None routine 

Ammonium Chloride
Ammonium chloride is used as an expectorant. It causes irritation of the bronchial mucosa, which results in the production of excess respiratory tract fluid. This allows for easier mucus expulsion due to its decreased viscosity.

Sorbimacrogol
Polysorbates are hydrophilic and are used as emulsifying agents for the preparation of stable oil-in- water emulsions in pharmaceutical products. Polysorbates may also be used for their surfactant properties in preparations for removal of ear wax, and for the management of dry eyes and upper respiratory tract disorders.

Ammonium Chloride/ Sorbimacrogol is available in several formulations. Please note the list below gives examples of products which are available and is not necessarily comprehensive. The listing of a product does not constitute endorsement of the product by EMGuidance; likewise, failure to list a product does not imply that EMGuidance disapproves of the product. This information is put together on the basis of the National Government's Medicines Price Registry at the time of publication

COMBINATION PREPARATIONS

Ammonium chloride/ Sorbimacrogol

Syrup (per 10ml) 34mg/ 36.33mg

• Expigen Cough Syrup (Adcock)