Aspirin/ Caffeine

Registered South African indications:

• Fever
• Pain

Contraindications

• Hypersensitivity to the active ingredient or any of the excipients in this combination product
• Pregnancy >30 weeks
• Breastfeeding
• Severe renal impairment
• Severe hepatic impairment
• Peptic ulcer
• History of peptic ulceration
• Haemophilia
• Children < 16 years
• Coadministration with anti-coagulant therapy

Cautions

• Pregnancy <30 weeks
• Mild to moderate renal impairment
• Mild to moderate hepatic impairment
• Asthma
• Allergic disease
• Dehydration

Forms avail. in SA and covered in this monograph: tab

Fever
Pain - mild to moderate

Aspirin/ Caffeine
400/ 22.70 (mg)
500/ 32.00 (mg)

• Oral (tab): 2 tab, 6hrly; Max: 8 tab/24hrs

Not established for use in children below 16 years

Recommendations for this combination product as per highest risk category when comparing individual active ingredients

Pregnancy

• <30 weeks: FDA Pregnancy Category C (Aspirin) 
• >30 weeks: FDA Pregnancy Category D (Aspirin) 

Breastfeeding

• Contraindicated

Renal Impairment

• Mild to moderate: Caution; no dose adjustment recommended 
• Severe: Contraindicated

Hepatic Impairment

• Mild to moderate: Caution; no dose adjustment recommended 
• Severe: Contraindicated

Elderly

• No dose adjustment recommended 

Porphyria Information

• Not porphyrinogenic (NP)

Drugs in Sport

• Permitted - No warning

Central Nervous System Disorders

• Tremor

Cardiovascular  Disorders

• Palpitations

Respiratory Disorders

• Bronchospasm
• Asthma attacks

Gastrointestinal Disorders

• Gastrointestinal irritation 
• Gastrointestinal haemorrhage

Endocrine and Metabolic Disorders

• Gout

Immune, Blood and Lymphatic System Disorders

• Hypersensitivity reactions
• Increased bleeding time

Others

• Reye's Syndrome

• Non-steroidal anti-inflammatory drugs
• Corticosteroids
• Diuretics
• Anticoagulants
• Metoclopramide
• Phenytoin
• Valproate
• Methotrexate

None routine. Specific cases may require

• Renal function
• Hepatic function

Aspirin
Acetyl salicylic acid inhibits the cyclooxygenase enzyme, thereby preventing production of prostaglandins and thromboxines. 

Caffeine
Caffeine is a nonspecific adenosine receptor antagonist and acts as a central nervous system stimulant.

COMBINATIONS PREPARATIONS

Aspirin/ Caffeine

Tablet 400mg/22,7mg 

• Anadin Tablets (S.A.D)

Tablet 500mg/32mg 

• Extra Strength Anadin Tablets (S.A.D)