Buclizine

Registered South African indications:

• Nausea and vomiting
• Appetite stimulant
• Allergic reactions

Contraindications

• Hypersensitivity to the active ingredient or any of its excipients
• Bladder neck obstruction
• Closed angle glaucoma
• Prostatic hypertrophy
• Pulmonary disease
• Pyeloduodenal obstruction
• Asthma

Cautions

• Pregnancy
• Breastfeeding
• Elderly
• Focal lesions of cerebral cortex
• Cardiovascular disorders
• May impair ability to drive and operate machinery

Forms avail. in SA and covered in this monograph: tab, syr

Motion sickness

• Oral (tab): 25-50mg, 1-2hrs before traveling

Allergic reactions
Appetite stimulation

• Oral (tab): 25-50mg, dly

Nausea and vomiting associated with chemotherapy/radiotherapy

• Oral (tab): 50mg, 6-8hrly; initiate therapy 1-2 days before exposure to chemo/radiotherapy

Paed. forms avail. in SA and covered in this monograph: tab

Motion sickness
Nausea and vomiting
Allergic reactions
Appetite stimulation

Younger than 5 years

• Not established for use

Between 5-12 years

• Oral (tab): 12.5-25mg, dly

Older than 12 years

• See adult dosage

Pregnancy

• FDA Pregnancy Category Not Rated (NR)

Breastfeeding

• Caution 

Renal Impairment

• No dose adjustment recommended

Hepatic Impairment

• No dose adjustment recommended

Elderly

• Caution; no dose adjustment recommended

Porphyria Information

• Not yet classified (NC)

Drugs in Sport

• Permitted - No warning

Central Nervous System Disorders

• Sedation
• Lassitude
• Dizziness
• Inco-ordination
• Euphoria
• Headache
• Insomnia
• Anxiety
• Irritability
• Tremor
• Seizures
• Hallucinations
• Nightmares

Cardiovascular Disorders

• Hypotension 

Respiratory Disorders

• Thickened respiratory tract secretions
• Tight chest

Gastrointestinal Disorders

• Gastric reflux
• Constipation
• Nausea and vomiting
• Dry mouth
• Diarrhoea
• Epigastric pain

Genitourinary Disorders

• Urinary difficulty
• Urinary retention

Musculoskeletal Disorders

• Muscular weakness

Sensory Disorders

• Tinnitus
• Blurred vision

Central nervous system depressants

None routine

Buclizine is a long-acting H1 receptor antagonist with antiemetic and anti-motion sickness properties. The exact mechanism is not not known, but it appears to diminish vestibular stimulation, depress labyrinthine function as well as modulating functioning of the medullary chemoreceptive trigger zone.

Tablet 25mg

• Vomifene (Adcock) originator