Cafedrine/ Theodrenaline [Discontinued in SA Market]

Registered South African indications:

• Hypotension

Contraindications

• Hypersensitivity to the active ingredient or any of the excipients in this combination product
• Hypertension
• Mitral stenosis
• Glaucoma
• Coadministration with beta-blockers

Cautions

• Pregnancy
• Breastfeeding
• Renal impairment
• Hepatic impairment
• Elderly

Forms avail. in SA and covered in this monograph: tab

Hypotension
- Primary
- Secondary
- Orthostatic

Cafedrine/Theodrenaline
100/5 (mg)

• Oral (tab): 1-2 tab, 12-24hrly, Downtitrate at intervals of 5-10 days

Paed. forms avail. in SA and covered in this monograph: tab

Hypotension
- Primary
- Secondary
- Orthostatic

Cafedrine/Theodrenaline
100/5 (mg)

• Oral (tab): 1 tab, dly

Pregnancy

• FDA Pregnancy Category Not Rated (NR)

Breastfeeding

• Caution

Renal Impairment

• Caution; no dose adjustment recommended

Hepatic Impairment

• Caution; no dose adjustment recommended

Elderly

• Caution; dose adjustment recommended

Porphyria Information

• Not yet classified (NC)

Drugs in Sport

• Permitted - No warning

Cardiovascular Disorders

• Palpitations
• Worsened angina
• Arrhythmias

Beta blockers

None routine

Cafedrine/Theodrenaline
Cafedrine/Theodrenaline has a positive inotropic effect on the heart (without increasing heart rate) and mediates vascular smooth muscle relaxation and contraction through its action on cardiac beta-1 adrenoceptors, vascular alpha-1 adrenoceptors, and phosphodiesterases.  These effects result in an increase in blood pressure through increased inotropy, stroke volume, minute volume, preload and cardiac output, while systemic vascular resistance remains largely unchanged. 

COMBINATION PREPARATIONS

Cafedrine/ Theodrenaline

Tablet 100mg/5mg

• Akrinor (Adcock) (Discontinued: 25/01/2020)