Cetylpyridinium Chloride

Registered South African indications:

• Sore throat
• Mouth infections
• Throat irritation
• Tickling cough
• Discomfort following periodontal procedures and minor mouth surgery

Contraindications

• Hypersensitivity to the active ingredient or any of its excipients

Cautions

• Pregnancy
• Breastfeeding
• Renal impairment
• Hepatic imapairment
• Prolonged use

Forms avail. in SA and covered in this monograph: sol

Sore throat  
- Secondary to colds
Mouth infections
Throat irritation and tickling cough
- Due to dust, allergy, smoke, excessive use of voice
Discomfort following periodontal procedures and minor mouth surgery 

• Oral (sol): Rinse mouth with small quantity, as often as needed

Do not swallow

May use diluted or undiluted

Not approved for use in South Africa for children.

Pregnancy

• Caution
• The use of cetylpyridinium chloride in pregnancy has not been studied but is unlikely to constitute a hazard

Breastfeeding

• Caution;
• The use of cetylpyridinium chloride in breastfeeding has not been studied but is unlikely to constitute a hazard

Renal Impairment

• Caution; no information available

Hepatic Impairment

• Caution; no information available

Elderly

• No dose adjustment recommended

Porphyria Information

• Not yet classified (NC)

Drugs in Sport

• Permitted - No warning

Gastrointestinal Disorders

• Nausea and vomiting

Sensory Disorders

• Dental discoloration
• Mouth irritation
• Tongue discoloration

No information available

None routine

Cetylpyridinium chloride is bactericidal against a wide variety of Gram-positive and Gram-negative bacteria which include haemolytic Streptococcus, Staphylococcus aureus, Escherichia coli and Lactobacillus acidophilus. Fungicidal action has been demonstrated against Monilia albicans, the cause of oral thrush.

Cetylpyridinium chloride is available in several formulations. Please note the list below gives examples of products which are available and is not necessarily comprehensive. The listing of a product does not constitute endorsement of the product by EMGuidance; likewise, failure to list a product does not imply that EMGuidance disapproves of the product. This information is put together on the basis of the National Government's Medicines Price Registry at the time of publication.

Oral Rinse (per 100ml) 50mg

• Cepacol (Adcock)