Chlorodyne/ Kaolin/ Pectin/ Sodium Lactate/ Potassium Chloride/ Sodium Chloride

Registered South African indications:

• Diarrhoea

Combination products may have additional pharmacological effects not accounted for by the action of the individual ingredients

Sodium Lactate
Contraindications

• Hypersensitivity to the active ingredient or any of the excipients in this combination product
• Severe renal impairment
• Severe hepatic impairment
• Lactic acidosis
• Severe acidosis
• Hypernatraemia
• Conditions where sodium administration would be harmful

Cautions

• Pregnancy
• Elderly
• Metabolic or respiratory acidosis
• Congestive heart failure
• Sodium retaining conditions
• Conditions impairing lactate utilization
• Diabetes mellitus

Potassium Chloride
Contraindications

• Hypersensitivity to the active ingredient or any of the excipients in this combination product
• Hyperkalaemia
• Severe renal impairment 
• Hyperchloraemia
• Addison's disease
• Acute dehydration and heat cramps

Cautions

• Pregnancy
• Breastfeeding
• Mild to moderate renal impairment
• Elderly
• Adrenal insufficiency  
• Intestinal stricture
• History of peptic ulcer
• Cardiac disease
• Acute dehydration or heat cramps
• Severe burns
• Myotonia congenita
• Severe haemolysis 
• Acidosis
• Hypertension

Sodium Chloride
Contraindications

• Hypersensitivity to the active ingredient or any of the excipients in this combination product
• Oedema
• Cardiovascular disease
• Cardiac decompensation
• Primary or secondary hyperaldosteronism
• Coadministration with diuretics

Cautions

• Mild to moderate renal impairment
• Elderly
• Hypertension
• Cardiac failure
• Pre-eclampsia
• Children
• Diabetes mellitus
• Hyperlipidaemia
• Conditions associated with sodium retention
• Hyperproteinaemia
• Low sodium diet

Forms avail. in SA and covered in this monograph: sus

Acute diarrhoea - Mild to moderate

Chlorodyne/ Kaolin/ Pectin/ Sodium Lactate/ Potassium Chloride/ Sodium Chloride
2ml/20g/0.4g/0.29g/0.14g/0.26g (per 100ml)

• Oral (sus): 20-40ml, 4hrly

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Ensure adequate hydration maintained

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Take with water

Paed. forms avail. in SA and covered in this monograph: sus

Acute diarrhoea - Mild to moderate

Chlorodyne/ Kaolin/ Pectin/ Sodium Lactate/ Potassium chloride/ Sodium chloride
2ml/20g/0.4g/0.29g/0.14g/0.26g (per 100ml)

• Younger than 3 years: Not established for use 
• Between 3-6 years: Oral (sus): 5-10ml, 4hrly
• Between 6-12 years: Oral (sus): 10-20ml, 4hrly
• Older than 12 years: See adult dosage

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Ensure adequate hydration maintained

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Take with water

Recommendations for this combination product as per highest risk category when comparing individual active ingredients

Pregnancy

• FDA Pregnancy Category Not Rated (NR) (Kaolin, Pectin, Sodium Lactate, Sodium Chloride)

Breastfeeding

• Caution (Kaolin, Pectin, Potassium Chloride)

Renal Impairment

• Mild to moderate: Caution; dose adjustment recommended (Potassium Chloride, Sodium Chloride)
• Severe: Contraindicated (Sodium Lactate, Potassium Chloride) 

Hepatic Impairment

• Severe: Contraindicated (Sodium Lactate)

Elderly

• Caution; dose adjustment recommended (Potassium Chloride)

Drugs in Sport

• Permitted - No warning

Combination products may have additional pharmacological effects not accounted for by the action of the individual ingredients

Sodium Lactate
Central Nervous System Disorders

• Anxiety
• Panic attacks
• Paraesthesia
• Tremor
• Dizziness
• Fear

Cardiovascular Disorders

• Tachycardia

Respiratory Disorders

• Dyspnoea

Endocrine and Metabolic Disorders

• Hypokalaemia
• Metabolic acidosis
• Hypocalcaemia
• Sweating

Musculoskeletal Disorders

• Myasthenia gravis

Potassium Chloride
Cardiovascular Disorders

• Arrhythmias 

Gastrointestinal Disorders

• Nausea and vomiting 
• Oesophageal ulceration
• Small bowel ulceration

Endocrine and Metabolic System Disorders

• Hyperkalaemia 

Skin and Subcutaneous Tissue Disorders 

• Pain at the injection site 
• Phlebitis 

Sodium chloride
Central Nervous System Disorders

• Headache
• Dizziness
• Restlessness
• Irritability
• Weakness
• Fever

Cardiovascular Disorders

• Tachycardia
• Hypertension
• Hypotension
• Oedema

Gastrointestinal Disorders

• Nausea and vomiting
• Diarrhoea
• Abdominal cramps
• Decreaesd salivation

Endocrine and Metabolic Disorders

• Sodium accumulation
• Hyperchloraemic acidosis
• Thirst

Musculoskeletal Disorders

• Muscular twitching
• Muscular rigidity

Skin and Subcutaneous Tissue Disorders

• Sweating

Sensory Disorders

• Reduced lacrimation

Combination products may have additional pharmacological effects not accounted for by the action of the individual ingredients

Sodium Lactate

• Corticosteroids
• Agents that increase serum potassium
• Ephedrine
• Dexamphetamine

Potassium chloride

• Potassium-sparing diuretics
• Angiotensin-converting enzyme inhibitors 
• Angiotensin II receptor antagonists 
• Ciclosporin 
• Blood transfusions 
• Digitalis 
• Thiazide diuretics 
• Tacrolimus 
• Beta blockers 
• Non-steroidal anti-inflammatory drugs 
• Drugs that contain potassium 
• Quinidine 
• Adrenocorticoids 
• Corticosteroids 
• Glucose Infusion

Sodium chloride

• Antihypertensives
• Lithium
• Diuretics

None routine. Specific cases may require

• Blood glucose
• Fluid balance
• Serum electrolytes

Chlorodyne
This ingredient has no pharmacological effect.

Kaolin
Kaolin adsorbs water, toxins and bacteria from the gastrointestinal tract, leading to firmer stools and reducing fluid loss.

Pectin
Pectin reduces stool volume.

Sodium Lactate
Sodium lactate has alkalinising effects due to its simultaneous removal of lactate and hydrogen ions.

Potassium Chloride
Potassium chloride is the principle cation of intracellular fluid. Potassium ions are involved in numerous cellular metabolic processes, including intracellular tonicity, transmission of nerve impulses, contraction of cardiac, smooth, and skeletal muscles and renal function.  It is also involved in synthesis of protein, metabolism of carbohydrate and storage of energy reserves.

Sodium Chloride
Sodium chloride is the principle salt involved in maintaining the osmotic tension in blood and tissues. Changes in osmotic tension influence the movement of fluids and diffusion of salts in cellular tissues.

COMBINATION PREPARATIONS

Kaolin/ Pectin/ Sodium lactate/ Sodium chloride/ Potassium chloride/ Chlorodyne
Suspension (per 100ml) 20g/0.4g/0.29g/0.26g/0.14g/2ml

• Pectrolyte (Adcock)