Choline Salicylate/ Cetalkonium Chloride

Registered South African indications:

• Pain
• Inflammation

Contraindications

• Hypersensitivity to the active ingredient or any of its excipients
• Active peptic ulceration
• Salicylate sensitivity

Cautions

• Pregnancy
• Breastfeeding
• Renal impairment
• Hepatic impairment
• Children younger than 16 years

Forms avail. in SA and covered in this monograph: gel

Pain and inflammation of the mouth (common mouth ulcers, cold sores, sore spots, dentures or orthodontic devices) 

• Topical (gel): Apply about 1cm to the tender area, 6-8hrly and at bedtime

Paed. forms avail. in SA and covered in this monograph: gel 

Pain and inflammation of the mouth (common mouth ulcers, cold sores, sore spots, dentures, orthodontic devices and teething) 

Younger than 2 years

• Topical (gel): Apply about 0.5cm to the tender area, 6-8hrly and at bedtime

Older than 2 years

• Topical (gel): Apply about 1cm to the tender area, 6-8hrly and at bedtime

Dosage represented above is from the SA approved Package insert (1979). Later international summary product characteristics (2015) note the following: ''Not to be used in children and adolescents under the age of 16. This is because there is a possible association between salicylates and Reye's syndrome when given to children''  

Pregnancy 

• FDA Pregnancy Category Not Rated (NR)

Breastfeeding 

• Caution

Renal Impairment 

• Caution; no information available

Hepatic Impairment  

• Caution; no information available

Elderly 

• No dosage adjustment recommended

Drugs in Sport

• Permitted - No warning

Respiratory Disorders

• Bronchospasm
• Asthma

Others 

• Slight tingling after application  

• Anticoagulants 
• Uricosurics

None routine 

Choline salicylate inhibits prostaglandin production. It may also have effects on leukotriene pathways, kinin release and nerve conduction. Cetalkonium chloride is an antimicrobial agent which is bactericidal towards both Gram positive and Gram negative organisms.

COMBINATION PREPARATIONS

Choline salicylate/ Cetalkonium chloride 
Gel (per mg) 87.1%/0.1%

• Bonjela (Reckitt Benckisser)
• Teejel (Adcock)