Dexchlorpheniramine (oral)

Contraindications

• Hypersensitivity to the active ingredient or any of its excipients
• Hypersensitivity to racemic chlorpheniramine

Cautions

• Pregnancy
• Breastfeeding
• Hepatic impairment
• Elderly
• Bladder neck obstruction
• Prostatic hypertrophy
• Bronchial asthma
• Narrow angle glaucoma
• Stenosing peptic ulcer or pyloroduodenal obstruction

Pregnancy

• Caution; no evidence of risk in studies
• Use of antihistamines during pregnancy has not been associated with an increased risk of adverse events. Specific information on dexchlorpheniramine is limited

Breastfeeding

• Caution
• Large doses or prolonged use might cause effect in the breastfed infant
• Although infant risk cannot be ruled out, small occasional doses would not be expected to cause any adverse effects in breastfed infants
• Non-sedating antihistamines such as loratidine are the preferred alternatives

Renal Impairment

• No dose adjustment recommended

Hepatic Impairment

• Caution; no dose adjustment recommended
  Alternative agents should be considered

Elderly

• Caution; no dose adjustment recommended

Porphyria Information

• Possibly porphyrinogenic (PSP)

Central Nervous System Disorders

• Dyskinesia
• Headache
• Somnolence
• Hallucination

Cardiovascular Disorders

• Arrythmia

Respiratory Disorders

• Dry nose

Gastrointestinal Disorders

• Anorexia
• Nausea and vomiting
• Epigastric distress
• Diarrhoea
• Constipation

Skin and Subcutaneous Tissue Disorders

• Contact dermatitis

Immune, Blood and Lymphatic System Disorders

• Agranlocytosis
• Aplastic anaemia
• Thrombocytopaenia

• Central nervous system depressants
• Donepezil
• Bupropion

Dexchlorpheniramine is a propylamine derivative anti-histamine of the alkylamine class that specifically blocks the H1 receptors.