Diethylpropion Hydrochloride [Discontinued in SA Market]

Please note that the products associated with this active ingredient monograph have all been discontinued in the South African market.

The information in this monograph has not been updated and remains on the EMGuidance platform for reference purposes only.

• Obesity - moderate to severe

Please note that the products associated with this active ingredient monograph have all been discontinued in the South African market.

The information in this monograph has not been updated and remains on the EMGuidance platform for reference purposes only.

Contraindications

• Hypersensitivity to the active ingredient or any of its excipients
• Idiosyncrasy to other sympathomimetic amines
• Emotionally unstable individuals who are known to be susceptible to drug or alcohol abuse or those with a history of psychiatric illness
• Uncontrolled thyrotoxicosis
• Moderate/severe hypertension
• Severe cardiovascular diseases
• Glaucoma
• Extrapyramidal disorders
• Hyperexcitability or agitated states
• Pregnancy
• Lactation
• Coadministration with monoamine oxidase inhibitors or within 14 days of their use

Cautions

• Renal impairment
• Hepatic impairment
• Elderly
• Anorexia
• Insomnia
• Epilepsy
• Prolonged use
• May impair ability to drive and operate machinery

Please note that the products associated with this active ingredient monograph have all been discontinued in the South African market.

The information in this monograph has not been updated and remains on the EMGuidance platform for reference purposes only.

Obesity - moderate to severe
- In conjunction with a reduced kilojoule intake and exercise (when close support and supervision are also provided)

• Oral (SR tab): 75mg, dly, mid-morning or 1hr before midday meal: For short-term use: Up to 12 weeks

Tablet should be swallowed whole

Please note that the products associated with this active ingredient monograph have all been discontinued in the South African market.

The information in this monograph has not been updated and remains on the EMGuidance platform for reference purposes only.

Not recommended for children under 12 years

Please note that the products associated with this active ingredient monograph have all been discontinued in the South African market.

The information in this monograph has not been updated and remains on the EMGuidance platform for reference purposes only.

Pregnancy

• Contraindicated
• There is inadequate evidence of safety in human pregnancy. The use of diethylpropion during any stage of pregnancy is not recommended. There is evidence from animal studies that the drug may be harmful to the foetus. Isolated spontaneous reports of congenital malformations have been recorded in humans, but no causal relationship to diethylpropion hydrochloride has been established

Breastfeeding

• Contraindicated
• The use of diethylpropion during lactation is not recommended

Renal Impairment

• Caution; no dose adjustment recommended

Hepatic Impairment

• Caution; no information available

Elderly

• Caution; not recommended

Please note that the products associated with this active ingredient monograph have all been discontinued in the South African market.

The information in this monograph has not been updated and remains on the EMGuidance platform for reference purposes only.

Psychiatric Disorders

• Euphoria (may be followed by fatigue and depression)
• Irritability
• Psychotic reactions

Nervous System Disorders

• Insomnia
• Nervousness
• Restlessness
• Headache
• Dizziness
• Tremor

Gastrointestinal Disorders

• Dryness of the mouth
• Anorexia
• Abdominal cramps and other gastrointestinal disturbances

Cardiac Disorders

• Tachycardia
• Palpitations

Vascular Disorders

• Increased blood pressure

Renal and Urinary Disorders

• Difficulty in micturition
• Muscle damage with associated renal complications

Reproductive System and Breast Disorders

• Altered libido and impotence

Skin and Subcutaneous Tissue Disorders

• Sweating

Musculoskeletal, Connective Tissue and Bone Disorders

• Muscle damage

Please note that the products associated with this active ingredient monograph have all been discontinued in the South African market.

The information in this monograph has not been updated and remains on the EMGuidance platform for reference purposes only.

• Guanethidine and similar antihypertensive agents
• Antidiabetic medications
• Psychotropic drugs
• Sympathomimetics
• Urinary alkalisers (reducing excretion of diethylpropion)
• Urinary acidifiers (increasing excretion of diethylpropion)

Please note that the products associated with this active ingredient monograph have all been discontinued in the South African market.

The information in this monograph has not been updated and remains on the EMGuidance platform for reference purposes only.

• Echocardiogram
• Weight
• Waist circumference
• Blood pressure

Specific cases may require

• Renal function
• Cardiovascular examination

Please note that the products associated with this active ingredient monograph have all been discontinued in the South African market.

The information in this monograph has not been updated and remains on the EMGuidance platform for reference purposes only.

Diethylpropion hydrochloride is a sympathomimetic, which is used as an anorectic agent.

Tablet SR 75mg

• Tenuate Dospan (Adcock)