Diiodohydroxyquinoline/ Benzocaine/ Chlorobutanol

Registered South African indications:

• Bacterial and fungal skin infections with itching

Combination products may have additional pharmacological effects not accounted for by the action of the individual ingredients

Diiodohydroxyquinoline
Contraindications 

• Hypersensitivity to the active ingredient or any of the excipients in this combination product
• Hepatic impairment

Cautions

• Pregnancy
• Breastfeeding
• Elderly
• Prolonged use
• High doses
• Thyroid disease

Benzocaine
Contraindications

• Hypersensitivity to the active ingredient or any of the excipients in this combination product
• Hypersensitivity to paraaminobenzoic acid, parabens or paraphenylenediamine or to commercial hair dyes
• History of allergy to local anaesthetics 
• Known or suspected methaemoglobinaemia 
• Coadministration with sulphonamides 
• Coadministration with cholinesterase inhibitors 

Cautions 

• Pregnancy
• Breastfeeding 
• Elderly 
• Complete heart block
• Application around mouth or eyes
• Application to large areas of damaged skin

Forms avail. in SA and covered in this monograph: cre

Bacterial and fungal infections complicated by itching

Diiodohydroxyquinoline/ Benzocaine/ Chlorobutanol
150/50/50 (mg)

• Topical (cre): Apply small amount to affected area, 8hrly

No information available

Recommendations for this combination product as per highest risk category when comparing individual active ingredients

Pregnancy

• FDA Pregnancy Category Not Rated (NR) (Diiodohydroxyquinoline) 
  

Breastfeeding

• Caution; no information available (Benzocaine)
  

Renal Impairment

• No dose adjustment recommended (Diiodohydroxyquinoline, Benzocaine)

Hepatic Impairment

• Contraindicated (Diiodohydroxyquinoline)

Elderly

• Caution; no dose adjustment recommended (Diiodohydroxyquinoline, Benzocaine)

Combination products may have additional pharmacological effects not accounted for by the action of the individual ingredients

Diiodohydroxyquinoline
Central Nervous System Disorders

• Chills
• Headache
• Peripheral neuropathy
• Vertigo
• Fever

Gastrointestinal Disorders

• Abdominal cramps
• Diarrhoea
• Nausea and vomiting
• Pruritus ani

Endocrine and Metabolic Disorders

• Goiter

Skin and Subcutaneous Tissue Disorders

• Pruritus
• Skin rash
• Urticaria

Sensory Disorders

• Optic atrophy
• Optic neuritis

Benzocaine
Skin and Subcutaneous Tissue Disorders

• Dermatitis 
• Pruritis 
• Localized oedema 
• Erythema
• Rash
• Urticaria 

Immune, Blood and Lymphatic System Disorders

• Hypersensitivity 
• Methaemoglobinaemia

Combination products may have additional pharmacological effects not accounted for by the action of the individual ingredients

Diiodohydroxyquinoline

• No information available

Benzocaine

• Sulphonamides
• Cholinesterase inhibitors

None routine

Diiodohydroxyquinoline
Diiodohydroxyquinoline is a quinoline derivative that can be used to treat amoebiasis; the exact mechanism of action is unknown. 

Benzocaine
Binds to sodium channels and reversibly stabilizes the neuronal membrane which decreases its permeability to sodium ions. Depolarization of the neuronal membrane is inhibited thereby blocking the initiation and conduction of nerve impulses.

Chlorobutanol
This ingredient has no pharmacological effect.

COMBINATION PREPARATIONS

Diiodohydroxyquinoline/ Benzocaine/ Chlorobutanol

Cream 150mg/50mg/50mg

• Viodor (Pharmacare)