Diphtheria Toxoid/ Tetanus Toxoid
Indications
Registered South African indications:
- Primary immunisation against tetanus and diptheria
- Routine booster immunisation against tetanus and diptheria
- Post-exposure prophylaxis
Cautions
Contraindications
- Hypersensitivity to the active ingredient or any of its excipients
- History of severe reaction to previous dose
- Infectious disease
- Evolving immunological disorder
Cautions
- Pregnancy
- Breastfeeding
- Avoid dose if booster or primary immunisation given in the last 5 years
- Immunosuppression
Adult dosage
Forms avail. in SA and covered in this monograph: inj
Primary immunisation
- IM: 0.5ml; Immunisation schedule: Give dose at 0, 1 and 2 months
Routine booster immunisation
- IM: 0.5ml, every 5-10 years
Post-exposure prophylaxis following a tetanus-prone wound
- IM: According to the following recommendations
|
Type of wound
|
Partially or unimmunized patient
|
Completely immunized
Time since last booster |
|
|
5-10 years
|
> 10 years
|
||
|
Clean - minor
|
Begin or complete immunization, Tetanus-diptheria (Td), 0.5ml
|
None
|
Td, 0.5ml
|
|
Major - clean or tetanus prone
|
In one arm: Tetanus immunoglobulin
+
In other arm: Td, 0.5ml
|
Td, 0.5ml
|
In one arm: Tetanus immunoglobulin
+
In other arm: Td, 0.5ml
|
|
Tetanus- prone or delayed or incomplete debridement
|
Td, 0.5ml
+
Antibiotic therapy
|
Td, 0.5ml
+
Antibiotic therapy
|
In one arm: Tetanus immunoglobulin
+
In other arm: Td, 0.5ml
+
Antibiotic therapy
|
DO NOT administer via IV route
Paediatric dosage
Paed. forms avail. in SA and covered in this monograph: inj
Primary immunisation
Younger than 12 years
- Not established for use
Older than 12 years
- See adult dosage
Routine booster immunisation
Younger than 6 years
- Not established for use
Older than 6 years
- See adult dosage
Post-exposure prophylaxis for wounds
Younger than 7 years
- Not established for use
Older than 7 years
- See adult dosage
DO NOT administer via IV route
Special populations
Pregnancy
Breastfeeding
Renal Impairment
Hepatic Impairment
Elderly
Adverse reactions
Central Nervous System Disorders
- Malaise
- Headache
- Shivering
Cardiovascular Disorders
- Hypotension
Musculoskeletal Disorders
- Local myalgia
- Arthralgia
Skin and Subcutaneous Tissue Disorders
- Local redness
- Swelling
- Pain at injection site
- Urticaria
- Pruritus
Immune, Blood and Lymphatic System Disorders
- Lymphadenopathy
- Fever
Interactions
No information available
Monitoring
None routine
Mechanism of action
Provides passive immunity towards diphtheria and tetanus by supplying antibodies to neutralize the free form of the toxins.
Dosage forms
- Vaccine
Formulation
COMBINATION PREAPARATIONS
Tetanus Toxoid/ Diptheria Toxoid
Injection 40iu/30iu
- Imovax Dt Adult/Diftavax (Sanofi) originator
References
1. SAMF_12th Edition_Page 357 2. https://drive.google.com/drive/folders/1zH46vegSZLgDQN_H-X3JZrXVs7G5Xy5d (10/2007_Sanofi_Diftavax)
Brands & products
1 product · cached snapshot- Imovax Dt Adult/Diftavax
VACVaccine· 1 product
from R102.10| Product | Strength | Pack | Applicant | Min price |
|---|---|---|---|---|
| Imovax DT Adult/Diftavax | 30 iu/0.5ml;iu/0.5ml | 1 | Sanofi Aventis South Africa (Pty) Ltd | R102.10 |
Medical aid coverage
data not yet integrated- Comprehensive Series—
- Executive Plan—
- KeyCare Series—
- Priority Series—
- Saver Series—
Formulary scraper pending — coverage tier, co-pay and authorisation requirements will appear here once data is ingested.
- BonClassic—
- BonComprehensive—
- BonEssential—
- BonFit Select—
- BonSave—
- BonStart—
Formulary scraper pending — coverage tier, co-pay and authorisation requirements will appear here once data is ingested.
- Beryl—
- Emerald—
- Onyx—
- Ruby—
- Sapphire—
- Tanzanite One—
Formulary scraper pending — coverage tier, co-pay and authorisation requirements will appear here once data is ingested.
- Aquarium Option—
- Efficiency Option—
- Marine Option—
Formulary scraper pending — coverage tier, co-pay and authorisation requirements will appear here once data is ingested.