Dipipanone Hydrochloride (oral)

Contraindications

• Hypersensitivity to the active ingredient or any of its excipients
• Severe renal impairment
• Severe hepatic impairment

Cautions

• Pregnancy
• Breastfeeding
• Mild to moderate renal impairment
• Mild to moderate hepatic impairment
• Elderly
• Diabetes mellitus
• Pheochromocytoma  
• Palliative care

Pregnancy

• Caution; no information available
• Avoid use

Breastfeeding

• Caution; not recommended
• Consider alternatives
• Opioids can significantly suppress lactation. Opioids are excreted in human milk, but the amount is generally considered to be less than 1% of any dose

Renal Impairment

• Mild to moderate: Caution; dose adjustment recommended

• Severe: Contraindicated

Hepatic Impairment

• Mild to moderate: Caution; no dose adjustment recommended
• Severe: Contraindicated

Elderly

• Caution; no information available
  Consider dose reduction and careful monitoring

Central Nervous System Disorders

• Dizziness
• Restlessness 
• Psychosis 
• Raised intracranial pressure 

Respiratory Disorders

• Respiratory depression

Gastrointestinal Disorders

• Nausea and vomiting

• Central nervous system depressants

Dipipanone is an opioid analgesic with pharmacologic actions similar to those of morphine but reported as less sedating than morphine. Dipipanone has a rapid onset of analgesia. It also has anticholinergic effects similar to atropine.