Ebastine

Registered South African indications:

• Allergic rhinitis
• Idiopathic chronic urticaria

Contraindications

• Hypersensitivity to the active ingredient or any of its excipients
• Pregnancy
• Breastfeeding

Cautions

• Long QT syndrome
• Hypokalaemia
• May impair ability to drive and operate machinery

Forms avail. in SA and covered in this monograph: tab

Allergic rhinitis
Urticaria

• Oral (tab): 10mg, dly

Paed. forms avail. in SA and covered in this monograph: tab

Allergic rhinitis
Urticaria

 Younger than 12 years

• Not established for use

Older than 12 years 

• See adult dosage

Pregnancy

• Contraindicated
• The safety of ebastine in pregnancy has not been established

Breastfeeding

• Contraindicated 
• The safety of ebastine in breastfeeding has not been established

Renal Impairment

• No dose adjustment recommended

Hepatic Impairment

• No dose adjustment recommended

Elderly

• No dose adjustment recommended

Porphyria Information

• Probably not porphyrinogenic (PNP)

Drugs in Sport

• Permitted - No warnings

Central Nervous System Disorders

• Headaches
• Asthenia
• Insomnia

Gastrointestinal Disorders

• Abdominal pain
• Dyspepsia
• Nausea

Sensory Disorders

• Epistaxis
• Rhinitis
• Sinusitis
• Dry mouth
• Pharyngitis

• CYP3A4 inhibitors
• Alcohol
• Central nervous system depressants

None routine

A long-acting and selective H1-receptor antagonist which binds on effector cells in the gastrointestinal tract, blood vessels, and respiratory tract, ameliorating the negative symptoms brought on by histamine.

Tablet 10mg

• Kestine (Pharmacare) originator