Emedastine

Registered South African indications:

• Conjunctivitis

Contraindications

• Hypersensitivity to the active ingredient or any of its excipients

Cautions

• Breastfeeding
• Renal impairment
• Hepatic impairment
• Elderly
• Extensive ocular surface disease
• Concomitant use of soft contact lenses

Forms avail. in SA and covered in this monograph: opd

Allergic conjunctivitis

• Ophthalmic (opd): 1 drop into affected eye(s), 12hrly

Paed. forms avail. in SA and covered in this monograph: opd

Allergic conjunctivitis

Younger than 4 years

• Not established for use 

Older than 4 years

• See adult dosage

Pregnancy

• FDA Pregnancy Category B 

Breastfeeding

• Caution 

Renal Impairment

• Caution; no information available

Hepatic Impairment

• Caution; no information available

Elderly

• Caution; no information available

Central Nervous System Disorders

• Abnormal dreams
• Headache
• Sinus headache
• Dysgeusia

Cardiovascular Disorders

• Tachycardia

Skin and Subcutaneous Tissue Disorders

• Rash

Sensory Disorders

• Eye pain
• Eye pruritus
• Conjunctival hyperaemia
• Decreased visual acuity
• Corneal infiltrates
• Corneal staining
• Eye irritation
• Dry eye
• Foreign body sensation in eyes
• Increased lacrimation
• Asthenopia
• Ocular hyperaemia

No information available

None routine

Emedastine is a potent selective histamine H1-receptor antagonist. Topical ocular administration of emedastine produces concentration-dependent inhibition of histamine-stimulated conjunctival vascular permeability.

Eye drops (per ml) 0.5mg

• Emadine (Novartis South Africa) originator