Etifoxine

Registered South African indications:

• Anxiety

Contraindications

• Hypersensitivity to the active ingredient or any of its excipients
• Severe renal impairment
• Severe hepatic impairment
• States of shock
• Myasthenia gravis
• Galactosaemia

Cautions

• Pregnancy
• Breastfeeding
• Mild to moderate renal impairment
• Mild to moderate hepatic impairment
• Elderly
• Glucose-galactose malabsorption
• Lactase deficit
• May impair ability to drive and operate machinery

Forms avail. in SA and covered in this monograph: cap

Psychosomatic manifestations of anxiety

• Oral (cap): 150-200mg/day, in 2-3 divided doses; Max duration: 8 weeks

Swallow the capsules with a little amount of water

No information available

Pregnancy

• Caution
• Taking into account the data available, it is preferable as a safety measure to avoid using etifoxine during pregnancy. Etifoxine crosses the placental barrier

Breastfeeding

• Caution; not recommended
• Taking into account the data available, it is preferable as a safety measure to avoid using etifoxine during breastfeeding

Renal Impairment

• Mild to moderate: Caution; no information available
• Severe: Contraindicated

Hepatic Impairment

• Mild to moderate: Caution; no information available
• Severe: Contraindicated

Elderly

• Caution; no information available

Porphyria Information

• Not yet classified (NC)

Drugs in Sport

• Permitted - No warnings

Central Nervous System Disorders

• Drowsiness

Skin and Subcutaneous Tissue Disorders

• Rash

Immune, Blood and Lymphatic System Disorders

• Allergic reactions
  - Angioedema
  - Urticaria

• Central nervous system depressants
• Morphine
• Morphine derivatives
• Benzodiazepines
• Sedative antihistamines
• Sedative antidepressants
• Central antihypertensives
• Baclofen
• Thalidomide
• Analegsics
• Antitussives
• Narcotic substitutes
• Hypnotics
• Neuroleptics
• Alcohol

None routine

Etifoxine hydrochloride belongs to the class of benzoxazine chemicals. It exerts its regulatory action on the autonomic nervous system, antagonises the behaviour, physiological and biochemical effects of anxiogenic stress without demonstrable dependence and a withdrawal syndrome.

Capsule 50mg

• Stresam (Adcock Ingram) originator