Fenoterol Hydrobromide

Registered South African indications:

To relieve reversible bronchospasm in obstructive airway disease such as asthma and congestive obstructive pulmonary disease in
- Bronchial asthma of varying aetiology
- Chronic and acute bronchitis
- Emphysema

Contraindications

• Hypersensitivity to the active ingredient and any of its excipients
• Hypersensitivity to other sympathomimetic amines
• Hyperthyroidism
• Congestive cardiac failure
• Idiopathic hypertrophic aortic stenosis
• Tachycardic dysrhythmias

Cautions

• Pregnancy 
• Breastfeeding 
• Uncontrolled diabetes mellitus
• Myocardial insufficiency
• Cardiac failure
• Angina pectoris
• Cardiac dysrrhythmias
• Hypertension
• Severe organic heart and vascular disorders
• Closed angle glaucoma
• Hyperthyroidism

Forms avail. in SA and covered in this monograph: liq, syr

To relieve reversible bronchospasm in obstructive airway disease such as asthma and congestive obstructive pulmonary disease in
- Bronchial asthma of varying aetiology
- Chronic and acute bronchitis
- Emphysema

• Oral (liq, syr): 2.5-5mg, 3 times dly 

Paed. forms avail. in SA and covered in this monograph: liq, syr

To relieve reversible bronchospasm in obstructive airway disease such as asthma and congestive obstructive pulmonary disease in
- Bronchial asthma of varying aetiology
- Chronic and acute bronchitis
- Emphysema

Infants

• Oral (liq, syr): 1.25mg, 2-3 times dly

Between 1-6 years:

• Oral (liq, syr): 1.25-2.5mg, 3 times dly

Between 6-12 years:

• Oral (liq, syr): 2.5mg, 3-4 times dly

Older than 12 years

• See adult dosage

Pregnancy

• Caution
• Safety has not been established. Fenoterol may inhibit uterine contrations

Breastfeeding

• Caution
• Safety in breastfeeding has not been established. Pre-clinical studies have shown that fenoterol is excreted into breast milk

Renal impairment

• No dose adjustment recommended 

Hepatic impairment

• No dose adjustment recommended

Elderly

• No dose adjustment recommended

Porphyria Information

• Probably not porphyrinogenic (PNP)

Drugs in Sport

• Prohibited - At all times

Central Nervous System Disorders 

• Fear
• Anxiety
• Restlessness
• Tremor
• Insomnia
• Confusion
• Irritability
• Psychotic states
• Headache
• Dizziness 

Cardiovascular Disorders 

• Palpitations
• Tachycardia
• Cardiac arrhythmia
• Angina pectoris
• Cardiac arrest
• Flushing

Respiratory Disorders 

• Cough
• Paradoxical bronchospasm
• Dyspnoea

Gastrointestinal Disorders 

• Nausea and vomiting
• Increased salivation 

Genitourinary Disorders 

• Dysuria
• Urinary retention

Endocrine and Metabolic Disorders 

• Altered metabolism
• Changes in blood sugar concentrations
• Decreased appetite

Muscularskeletal Disorders 

• Weakness

• Beta-2 agonists 
• Sympathomimetics
• Anticholinergics 
• Xanthine derivatives 
• Cardiac glycosides 
• Quinidine
• Monoamine oxidase inhibitors
• Tricyclic antidepressants
• Corticosteroids 
• Diuretics

None routine

Fenoterol hydrobromide is a selective beta-2 agonist which acts in the lungs to cause relaxation of bronchial smooth muscle thus relieving bronchospasm.

Syrup (per 5ml) 2.5mg

• Berotec 0.05% (Ingelheim) originator
• Fenovent (Pharmacare)

Also available in the following form: Nebuliser solution.