Homatropine

Registered South African indications: 

• Mydriatic
• Cycloplegic

Contraindications

• Hypersensitivity to the active ingredient or any of its excipients
• Closed angle glaucoma
• Narrow angle between iris and cornea

Cautions

• Pregnancy
• Breastfeeding
• Elderly
• Prolonged use
• Extensive ocular surface disease
• Infants < 3 months

Forms avail. in SA and covered in this monograph: opd

Refraction

• Ophthalmic (opd): 2 drops into eye(s); Repeat 2-3 times at 5-10min intervals

Uveitis/iritis

• Ophthalmic (opd): 1-2 drops into affected eye(s), every 3-4hrs

Mydriatics and cycloplegics are the outcome of this therapy which fit both refraction and therapy [in this case uveitis & iritis]

Care should be taken to avoid contact between the dropper-tip and the eye, eyelashes or any other surface

See adult dosage

Pregnancy

• FDA Pregnancy Category C

Breastfeeding

• Caution

Renal Impairment

• No dose adjustment recommended

Hepatic Impairment

• No dose adjustment recommended

Elderly

• Caution; no dose adjustment recommended

Immune, Blood and Lymphatic System Disorders

• Hypersensitivity

Sensory Disorders

• Conjunctivitis
• Increase intraocular pressure

• Acetylcholinesterase inhibitors
• Aclidinium
• Analgesics 
• Anticholinergic agents
• Cannabinoid-containing products
• Chloral betaine
• Cimetropium
• Eluxadoline
• Gastrointestinal agents 
• Glucagon
• Glycopyrrolate 
• Ipratropium
• Itopride
• Levosulpiride
• Mianserin
• Mirabegron
• Nitroglycerin
• Onabotulinumtoxin A
• Oxatomide
• Potassium chloride
• Pramlintide
• Ramosetron
• Rimabotulinumtoxin B
• Secretin
• Thiazide and thiazide-like diuretics
• Tiotropium
• Topiramate

None routine. Specific cases may require

• Intraocular pressure

Homatropine contains homatropine hydrobromide which blocks the action of certain parasympathetic nerves and cholinergic drugs. In ophthalmology, homatropine is used for its mydriatic and cycloplegic effects. Its peripheral effects are much weaker than those of atropine. It is preferred to atropine for diagnostic purposes because its onset is more rapid, it's duration less prolonged and it is readily controlled by physostigmine.

Eye drops (per ml) 20mg

• Isopto homatropine 20% (Alcon) originator