Iodine/ Potassium iodide
Indications
South African indications:
- Hyperthyroidism
Cautions
Contraindications
- Hypersensitivity to the active ingredient or any of its excipients
- Pregnancy
- Breastfeeding
- Hypocomplimentaemic vasculitis
- Dermatitis herpetiformis
- Nodular thyroid disease with heart disease
- Active tuberculosis
Cautions
- Renal impairment
- Prolonged use
- Adrenal insufficiency
- History of hyperthyroidism
- Tuberculosis
- Cardiac disease
- Acute bronchitis
- Children
Adult dosage
Forms avail. in SA and covered in this monograph: sol
Pre-operative to thyroidectomy
- Oral (sol): 2-6 drops, well diluted in milk or water, 8hrly; Treatment duration: Approx. 10 days pre-surgery
Thyrotoxic crisis/ thyroid storm
- Oral (sol): 4-8 drops, well diluted in milk or water, 6-8hrly; At least 1hr following first dose of antithyroid agent
Paediatric dosage
See adult dosage
Special populations
Pregnancy
Breastfeeding
Renal Impairment
Hepatic impairment
Elderly
Adverse reactions
Central Nervous System Disorders
- Depression
- Insomnia
- Impotence
- Headache
Respiratory Disorders
- Acute rhinitis
- Coryza-like symptoms
- Swelling and inflammation of the throat
- Pulmonary oedema
- Dyspnoea
- Bronchitis
Gastrointestinal Disorders
- Increased salivation
- Burning or painful mouth
- Nausea and vomiting
- Diarrhoea
Endocrine and Metabolic Disorders
- Goitre
- Hypothyroidism (Wolff-Chaikoff effect)
- Hyperthyroidism (Jod-Basedow effect)
Musculoskeletal Disorders
- Arthralgia
Skin and Subcutaneous Tissue Disorders
- Urticaria
- Acneform
- Severe eruption (iododerma)
Immune, Blood and Lymphatic System Disorders
- Allergic reactions
- Angioedema
- Purpura
- Fever
- Lymphadenopathy
- Eosinophilia
Sensory Disorders
- Metallic taste
- Conjunctivitis
Interactions
- Eplerenone
- Potassium-sparing diuretics
- Sodium iodide I131
- Vitamin K antagonists
Monitoring
Thyroid function tests
Mechanism of action
Iodine rapidly inhibits release of thyroid hormones from the thyroid gland. It also inhibits iodide uptake into the gland as well as organification of iodide. Iodine aqueous solution is given to render the thyroid firm and avoid the increased vascularity and friability with increased risk of haemorrhage that may result from the use of an antithyroid agent alone.
Dosage forms
- Solution
Formulation
Potassium iodide
Solution (per 100ml) 5g/10g
- Aqueous Iodine Oral solution (BP) (syn. Lugol's solution, Strong Iodine Solution USP)
References
1. SAMF_12th Edition_Page 266 2. https://www.medicines.org.uk/emc/medicine/25154 (02/12/2014_Thornton_Aqueous Iodine_oral sol) 3. https://drive.google.com/drive/search?q=iodine _ Pharmacologist (ref 3-12) 4.. https://www.drugs.com/pro/sski-oral-solution.html 5..https://www.uptodate.com/contents/potassium-iodide-and-iodine-lugol-solution-drug-information?search=iodine%20solution&source=search_result&selectedTitle=1~128&usage_type=default&display_rank=1#F802376 3 Martindale complete drug manual. 4. Afritox. 5. PubChem, US National Library of Medicines. 6. Micromedex solutions. 7. Drugs during pregnancy and lactation, 3 rd edition. 8. SAMF 12 th edition. 9. AMA Drug Evaluations, 6th. American Medical Association, Chicago, IL,1986. 10. Sterling JB & Heymann WR: Potassium iodide in dermatology: A 19t hcentury drug for the 21st century-uses, pharmacology, adverse effects, and contraindications. J Am Acad Dermatol 2000; 43:691-697. 11. Hurrell RF: Bioavailability of iodine. Eur J Clin Nutr 1997; 51(suppl 1):S9-S12. 12. www.clinicalkey-com.ez 13. https://www.drugs.com/pro/sski-oral-solution.html 14.https://www.uptodate.com/contents/potassium-iodide-and-iodine-lugol-solution-drug-information?search=iodine%20solution&source=search_result&selectedTitle=1~128&usage_type=default&display_rank=1#F802376
Brands & products
0 products · cached snapshot- Aqueous Iodine Oral Solution BP (syn. Lugol's solution
- Strong Iodine Solution USP)Aqueous Iodine Oral Solution BP
Medical aid coverage
data not yet integrated- Comprehensive Series—
- Executive Plan—
- KeyCare Series—
- Priority Series—
- Saver Series—
Formulary scraper pending — coverage tier, co-pay and authorisation requirements will appear here once data is ingested.
- BonClassic—
- BonComprehensive—
- BonEssential—
- BonFit Select—
- BonSave—
- BonStart—
Formulary scraper pending — coverage tier, co-pay and authorisation requirements will appear here once data is ingested.
- Beryl—
- Emerald—
- Onyx—
- Ruby—
- Sapphire—
- Tanzanite One—
Formulary scraper pending — coverage tier, co-pay and authorisation requirements will appear here once data is ingested.
- Aquarium Option—
- Efficiency Option—
- Marine Option—
Formulary scraper pending — coverage tier, co-pay and authorisation requirements will appear here once data is ingested.