Ketoprofen

Registered South African indications:

• Pain
• Inflammation

Contraindications 

• Hypersensitivity to the active ingredient or any of its excipients
• The third trimester of pregnancy
• Severe renal impairment
• Severe hepatic impairment
• History of hypersensitivity reactions such as bronchospasm, asthmatic attacks, rhinitis, angioedema, urticaria or other allergic-type reactions to ketoprofen, any other ingredients in this medicine, acetylsalicylic acid or other non-steroidal anti-inflammatory drugs. Severe, rarely fatal, anaphylactic reactions have been reported in such patients
• Severe heart failure
• Active peptic ulcer or any history of gastrointestinal bleeding, ulceration or perforation
• Haemorrhagic diathesis

Cautions 

• Pregnancy <30 weeks
• Breastfeeding
• Mild to moderate renal impairment
• Mild to moderate hepatic impairment
• Elderly
• History of hypertension
• Mild to moderate congestive heart failure
• Ischaemic heart disease
• Peripheral arterial disease
• Cerebrovascular disease
• Respiratory disorders
• Gastrointestinal bleeding, ulceration and perforation
• Systemic lupus erythematosus and mixed connective tissue disease
• Dehydration 

Forms avail. in SA in this monograph: ER cap

Rheumatoid arthritis
Osteoarthritis 

• Oral (ER cap): 200mg, dly

Take with food or milk 

Ketoflam (sustained-release capsules) is not intended for initial therapy

Not established for use in children

Pregnancy

• First and second trimester: Caution
• Third trimester: Contraindicated

Breastfeeding

• Caution; not recommended

Renal Impairment

• Mild to moderate: Caution; no dose adjustment recommended
• Severe: Contraindicated

Hepatic Impairment

• Mild to moderate: Caution; no dose adjustment recommended
• Severe: Contraindicated

Elderly

• Caution; no dose adjustment recommended

Central Nervous System Disorders

• Headache
• Dizziness
• Somnolence
• Paraesthesia
• Convulsions
• Dysgeusia
• Depression
• Confusion
• Hallucinations
• Vertigo
• Malaise
• Drowsiness
• Aseptic meningitis 

Cardiovascular Disorders

• Heart failure
• Oedema
• Hypertension
• Vasodilatation

Respiratory Disorders

• Asthma
• Bronchospasm 
• Rhinitis
• Non-specific allergic reactions
• Dyspnoea

Gastrointestinal Disorders

• Dyspepsia
• Nausea and vomiting
• Abdominal pain
• Constipation
• Diarrhoea
• Flatulence
• Gastritis
• Stomatitis
• Peptic ulcer
• Pancreatitis 
• Exacerbation of colitis and Crohn's disease
• Gastrointestinal haemorrhage
• Perforation
• Melaena
• Haematemesis
• Gastrointestinal bleeding 

Hepatobiliary Disorders

• Hepatitis
• Increased serum transaminases
• Elevated serum bilirubin
• Abnormal liver function
• Jaundice

Genitourinary Disorders

• Renal failure
• Tubulointerstitial nephritis
• Nephritic syndrome

Skin and Subcutaneous Tissue Disorders

• Pruritis
• Photosensitivity reactions
• Alopecia
• Urticaria
• Angioedema
• Bullous eruption 
• Stevens-Johnson syndrome 
• Toxic epidermal necrolysis 
• Exfoliative and bullous dermatoses 
• Purpura

Immune, Blood and and Lymphatic System Disorders

• Haemorrhagic anaemia
• Agranulocytosis
• Thrombocytopenia
• Bone marrow failure
• Neutropenia
• Anaphylactic reactions

Sensory Disorders

• Visual disturbances such as blurred vision 
• Optic neuritis
• Tinnitus

• Anticoagulants 
• Platelet aggregation inhibitors 
• Methotrexate
• Lithium
• Non-steroidal anti-inflammatory drugs 
• Mifepristone
• Pentoxifylline
• Diuretics
• Cardiac glycosides
• Ciclosporin
• Corticosteroids
• Quinolone antibiotics
• Tacrolimus
• Thrombolytic agents
• Probenecid
• Selective serotonin reuptake inhibitors 
• Angiotensin-converting enzyme inhibitors
• Angiotensin II blockers
• Zidovudine

None routine. Specific cases may require

• Renal function
• Hepatic function

Inhibits prostaglandin synthesis by inhibition of cyclooxygenase.

Capsule sr 200mg

• Ketoflam (Adcock) originator

Also available in the following form: Gel.