Lidocaine/ Fluorescein

Registered South African indications: 

• Ophthalmic diagnosis
• Local anaesthesia

Contraindications

• Hypersensitivity to the active ingredients or any of the excipients in this combination product
• Hypersensitivity to amide-type local anaesthetics

Cautions

• Pregnancy
• Renal impairment
• Hepatic impairment
• Use in an inflamed eye

Forms avail. in SA and covered in this monograph: opd

Combined diagnostic stain and topical anaesthetic

Lidocaine/ Fluorescein
20/1.25 (mg/0.5ml)

• Ophthalmic (opd): 1 or more drops, as directed by ophthalmologist

Systemic absorption may be reduced by compressing the lacrimal sac at the medial canthus for a minute during and following the instillation of the drops

Paed. forms avail. in SA and covered in this monograph: opd

Combined diagnostic stain and topical anaesthetic

Lidocaine/ Fluorescein
20/1.25 (mg/0.5ml)

• Ophthalmic (opd): As directed by ophthalmologist

Systemic absorption may be reduced by compressing the lacrimal sac at the medial canthus for a minute during and following the instillation of the drops

Recommendations for this combination product as per highest risk category when comparing individual active ingredients

Pregnancy

• FDA Pregnancy Category Not Rated (NR) (Fluorescein)

Breastfeeding

• Compatible

Renal Impairment

• Caution; no information available

Hepatic Impairment

• Caution; no information available

Elderly

• No dose adjustment recommended

Skin and Subcutaneous Tissue Disorders

• Urticaria
• Rash

Immune, Blood and Lymphatic System Disorders

• Anaphylactic reaction

Sensory Disorders

• Allergic conjunctivitis
• Peri-orbital oedema

No information available

None routine

Lidocaine
Lidocaine inhibits the ionic refluxes required for the initiation and conduction of impulses, thereby stabilising the neuronal membrane. After absorption, lidocaine may cause stimulation of the central nervous system followed by depression, and in the cardiovascular system, it acts primarily on the myocardium where it may produce a decrease in electrical excitability, conduction rate and force of contraction. Lidocaine causes a reversible blockade of impulse propagation along nerve fibres by preventing the inward movement of sodium ions through the nerve membrane.

Fluorescein
Fluorescein sodium is used as an ophthalmologic diagnostic tool for corneal abrasions, corneal ulcers, herpetic corneal infections, and dry eye. Fluorescein does not stain a normal cornea but conjunctival abrasions are stained yellow or orange, corneal abrasions or ulcers are stained a bright green and foreign bodies are surrounded by a green ring.

COMBINATION PREPARATIONS

Lidocaine/ Fluorescein

Eye drops (per 0.5ml) 20mg/1.25mg

• Minims Lidocaine & Fluorescein (Bausch & Lomb) originator