Lignocaine/ Noradrenaline

Registered South African indications:

• Local anaesthesia

Contraindications

• Hypersensitivity to the active ingredient or any of the excipients in this combination product 

Cautions

• Pregnancy 
• Breastfeeding
• Renal impairment 
• Hepatic impairment 
• Elderly 
• Impaired cardiac conduction

Forms avail. in SA and covered in this monograph: inj

Local anaesthesia
- Dental extractions and procedures 

Lignocaine/ Noradrenaline
20mg/12.5μg (per ml) 

• Local infiltration: 1.8ml; Max: 25ml/procedure

Extended procedures may require 3-10ml

Dosage will depend on the anaesthetic requirements as determined by the nature, magnitude, duration and locality of the operation

No information available 

Pregnancy

• FDA Pregnancy Category Not Rated (NR)

Breastfeeding

• Caution 

Renal Impairment

• Caution; no information available

Hepatic Impairment 

• Caution; no dose adjustment recommended

Elderly 

• Caution; no information available 

Porphyria Information

• Probably not porphyrinogenic (PNP)

Drugs in Sport

• Permitted - No warning

Central Nervous System Disorders

• Seizures 

Cardiovascular Disorders

• Hypotension
• Arrhythmias
• Circulatory collapse 

Respiratory Disorders

• Respiratory collapse 

Gastrointestinal Disorders

• Nausea and vomiting 

Musculoskeletal Disorders

• Muscular twitching 

Skin and Subcutaneous Tissue Disorders

• Pallor 
• Sweating 

Immune, Blood and Lymphatic System Disorders

• Hypersensitivity 

Tricyclic antidepressants 

None routine 

Lignocaine
Lignocaine inhibits the ionic refluxes required for the initiation and conduction of impulses, thereby stabilising the neuronal membrane. After absorption ligocaine may cause stimulation of the central nervous system followed by depression, and in the cardiovascular system, it acts primarily on the myocardium where it may produce a decrease in electrical excitability, conduction rate and force of contraction. Lignocaine causes a reversible blockade of impulse propagation along nerve fibres by preventing the inward movement of sodium ions through the nerve membrane.

Noradrenaline
Noradrenaline is a peripheral vasoconstrictor which acts on alpha adrenergic receptors. It is also an inotropic stimulator of the heart and dilator of coronary arteries as a result of its activity at the beta adrenergic receptors.

COMBINATION PREPARATION

Lignocaine/ Noradrenaline

Injection (per ml) 20mg/12.5μg

• Xylotox L (Adcock) originator