Lincomycin

These indications are based on manufacturer information for both originator and generic products. For product specific registered indications, please refer to product specific manufacturer information

Registered South African indications:

• Serious infections due to susceptible strains of streptococci, pneumococci and staphylococci

Contraindications

• Known hypersensitivity to the active ingredient or any of its excipients
• Known hypersensitivity to clindamycin
• Not indicated in the treatment of minor bacterial infections or viral infections

Cautions

• Pregnancy
• Breastfeedinng
• Severe renal impairment
• Hepatic impairment
• Elderly
• Prolonged use
• Severe allergies
• History of asthma
• Gastrointestinal disease
• Neonates

Forms avail. in SA and covered in this monograph: inj

Infections caused by Gram positive, aerobic cocci (excluding S. faecalis)

General dosing range

• IM: 600mg, 12-24hrly
• IV: 600-1000mg, 8-12hrly, infused over at least 1hr; Max: 8g/24hrs
• Ophthalmic (subconjunctival): 75mg, as a single dose

See additional prescribing points for administration directions

Paed. forms avail. in SA and covered in this monograph: inj

Infections caused by Gram positive, aerobic cocci (excluding S. faecalis)

General dosing range

Younger than 1 month old

• Not established for use

Older than 1 month old

• IM: 10mg/kg, 12-24hrly
• IV: 10-20mg/kg/day, in divided doses 8-12hrly, infused over at least 1hr; Max: 8g/24hrs

Pregnancy

• FDA Pregnancy Category C

Breastfeeding

• Caution; not recommended

Renal Impairment

• Severe: Caution; dose adjustment recommended

Hepatic Impairment

• Caution; no dose adjustment recommended

Elderly

• Caution; no dose adjustment recommended

Cardiovascular Disorders

• Hypotension 
• Cardiopulmonary arrest

Gastrointestinal Disorders

• Glossitis
• Stomatitis
• Nausea and vomiting
• Abdominal distress
• Persistent diarrhoea
• Enterocolitis
• Pruritus ani 
• Oesophagitis

Hepatobiliary Disorders

• Jaundice 
• Abnormal hepatic function tests

Genitourinary Disorders

• Azotemia
• Oliguria
• Proteinuria

Skin and Subcutaneous Tissue Disorders

• Pruritis
• Skin rashes
• Urticaria
• Vaginitis 
• Exfoliative and vesiculobullous dermatitis 
• Local irritation
• Pain
• Induration 
• Sterile abscess formation
• Thrombophlebitis

Immune, Blood and Lymphatic System Disorders

• Neutropenia
• Leucopenia
• Agranulocytosis 
• Thrombocytopenic purpura
• Aplastic anaemia 
• Pancytopenia
• Angioneurotic oedema
• Serum sickness 
• Anaphylaxis
• Erythema multiforme
• Stevens-Johnson syndrome

Sensory Disorders

• Tinnitis
• Vertigo

• BCG 
• Cholera vaccine
• Erythromycin 
• Mecamylamine
• Sodium picosulfate
• Typhoid vaccine

• Full blood count with differential
• Renal function
• Hepatic function

Administration directions

IV

Compatible with ringers, dextrose and lactate containing solutions

Lincomycin inhibits protein synthesis by specifically binding on the 50S subunit and affecting the process of peptide chain initiation. It has been shown to be effective against most of the common gram-positive pathogens. Depending on the sensitivity of the organism and concentration of the antibiotic, it may be either bactericidal or bacteriostatic.

Spectrum of activity: Gram positive, aerobic cocci (excluding S. faecalis)

Injection (per 2ml) 600mg

• Linocin (Pfizer) orginator