Magnesium Aspartate

Registered South African indications: 

• Magnesium deficiency

Contraindications

• Hypersensitivity to the active ingredient or any of its excipients
• Severe renal impairment (glomerular filtration rate <30ml/min)
• Cardiovascular conduction disorders (bradycardia)

Cautions

• Pregnancy
• Mild to moderate renal impairment
• Hepatic impairment
• Prolonged use
• Fructose intolerance
• Glucose-galactose malabsorption 
• Sucrase-isomaltase insufficiency

Forms avail. in SA and covered in this monograph: tab, gra

Magnesium deficiency

• Oral (tab, gra): 1230mg, 8hrly; Treatment duration: 4 weeks

Granules shoud be dissolved in 1/2 glass water, tea or juice and taken before meals

Tablets should be taken with water, before meals

Not established for use in children below 10 years

Pregnancy

• Caution
• A large amount of data on pregnant women over 16 weeks gestation (more than 1000 pregnancy outcomes) indicate no malformative nor feto/neonatal toxicity of magnesium
• Magnesium aspartate can be used during pregnancy if clinically needed
• Administration of aminoglycoside antibiotics should be avoided during this period, as there are indications of interactions

Breastfeeding

• Compatible
• Magnesium aspartate can be used during breastfeeding
• Magnesium aspartate/metabolites are excreted in human milk, but at therapeutic doses of Magnesium aspartate no effects on the breastfed newborns/infants are anticipated

Renal Impairment

• Mild to moderate (GFR>30ml/min): Caution; no dose adjustment recommended 
• Severe (GFR<30ml/min): Contraindicated

Hepatic Impairment

• Caution; no dose adjustment recommended

Elderly

• No dose adjustment recommended

Porphyria Information

• Not yet classified (NC)

Drugs in Sport

• Permitted - No warnings

Central Nervous System Disorders

• Fatigue

Gastrointestinal Disorders

• Soft stools 
• Diarrhoea 

• Cellulose sodium phosphate
• Edetate disodium
• Fluorides 
• Tetracycline
• Aminoquinolines
• Quinidine 
• Quinidine derivatives 
• Nitrofurantoin
• Penicillamine
• Iron
• Bisphosphonates
• Eltrombopag
• Nitroxoline
• Aminoglycosides 
• Cisplatinum 
• Ciclosporin A
• Diuretics
• EGF-receptor antagonists
• Proton pump inhibitors 
• Foscarnet
• Pentamidine
• Rapamycin 
• Amphotericin B

None routine

Magnesium is essential for the activity of many enzyme systems and plays an important role with regard to neuro-chemical transmission and muscular excitability.

Magnesium aspartate is available in several formulations. Please note the list below gives examples of products which are available and is not necessarily comprehensive. The listing of a product does not constitute endorsement of the product by EMGuidance; likewise, failure to list a product does not imply that EMGuidance disapproves of the product. This information is put together on the basis of the National Government's Medicines Price Registry at the time of publication

Granules (per 5g) 1229,6mg

• Magnesit (Nycomed)

Tablet 614,8mg

• Magnesit (Nycomed)