Measles/ Mumps/ Rubella/ Varicella (MMRV)

Registered South African indications:

• Immunisation against measles, mumps, rubella and varicella-zoster viruses

Contraindications

• Hypersensitivity to the active ingredient or to any of the excipients in this combination product
• Hypersensitivity to neomycin (except history of contact dermatitis)
• Hypersensitivity after previous administration of measles, mumps, rubella and/or varicella vaccines
• Pregnancy, and pregnancy should be avoided for one month after vaccination
• Severe humoral or cellular (primary or acquired) immunodeficiency

Cautions

• Breastfeeding
• Elderly
• Children between 12-23 months of age
• Acute illness
• Central nervous system disorders
• Personal or family history of seizures
• Human immunodeficiency virus infection
• Thrombocytopaenia
• Egg allergy
• Post-exposure prophylaxis

Not indicated for use in adults

Forms avail. in SA and covered in this monograph: inj

Immunisation against measles, mumps, rubella and varicella-zoster viruses

Younger than 9 months

• Not established for use

Between 9 months - 12 years

• SC: 0.5ml, as a single dose; Second dose given after 6 weeks

A single dose of this combination vaccine may be administered to children who have already received a single dose of another measles, mumps and rubella (MMR) vaccine and/or a single dose of another varicella vaccine

Pregnancy

• Contraindicated
• Animal studies have not been carried out
• Pregnancy should be avoided for one month after vaccination

Breastfeeding

• Not indicated for use in adults
• The rubella component of the vaccine may be excreted into breast milk
• It is unknown if the measles, mumps, or varicella components of the vaccine are excreted into breast milk
• The vaccine should not be given to breastfeeding women

Renal Impairment

• No dose adjustment recommended

Hepatic Impairment

• No dose adjustment recommended

Elderly

• Not indicated for use in geriatric patients

Porphyria Information

• Not yet classified (NC) 

Drugs in Sport

• Permitted - No warnings

Central Nervous System Disorders

• Irritability
• Crying
• Nervousness
• Insomnia
• Febrile seizures

Respiratory Disorders

• Rhinitis
• Cough
• Bronchitis

Gastrointestinal Disorders

• Parotid gland enlargement
• Diarrhoea
• Vomiting

Endocrine and Metabolic Disorders

• Anorexia

Skin and Subcutaneous Tissue Disorders

• Rash

Immune, Blood and Lymphatic System Disorders

• Lymphadenopathy

Sensory Disorders

•  Otitis media

• 5-aminosalicylic acid derivatives
• Azathioprine
• Belimumab
• Corticosteroids
• Daclizumab
• Dimethylfumarate
• Dupilumab
• Fingolimod
• Immune globulins
• Immunosuppressants
• Leflunomide
• Mercaptopurine
• Methotrexate
• Neomycin
• Ocrelizumab
• Blood and blood products
• Rabies immunoglobulin
• Rho (D) immune globulin 
• Salicylates
• Tisagenlecleucel
• Tuberculin test
• Venetoclax
• Live vaccines

None routine

The measles/ mumps/ rubella and varicella (MMRV) vaccine is a live, attenuated virus vaccine that induces active immunity to conditions caused by the measles, mumps, rubella, and varicella-zoster viruses.

Live attenuated measles virus (Schwarz strain)/ Live attenuated varicella virus (Oka strain)/ Live attenuated rubella virus (Wistar Ra 27/3 strain)/ Live attenuated mumps virus (Rit4385 strain)

Injection 0.5ml

• Priorix Tetra (GSK) originator