Mebeverine

Registered South African indications:

• Irritable colon secondary to organic lesions and inflammatory conditions of the gastrointestinal tract
• Irritable bowel syndrome

Contraindications

• Hypersensitivity to the active ingredient or any of its excipients

Cautions

• Pregnancy 
• Breastfeeding
• Galactose intolerance
• Lapp lactase deficiency  
• Glucose-galactose malabsorption  
• Fructose intolerance
• Sucrase-isomaltase insufficiency

Forms avail. in SA and covered in this monograph: tab

Irritable bowel syndrome
Irritable colon secondary to organic lesions and inflammatory conditions of the gastrointestinal tract

• Oral (tab): 135mg, 8hrly

Dose should be taken 20min before meals

If one or more doses are missed, the patient should continue with the next dose as prescribed, the missed dose(s) should not be taken in addition to the regular dose

Not established for use in children below 18 years

Pregnancy

• Caution
• There are no or limited amounts of data from the use of mebeverine in pregnant women. Animal studies are insufficient with respect to reproductive toxicity. Mebeverine is not recommended during pregnancy

Breastfeeding

• Caution; not recommended
• It is unknown whether mebeverine or its metabolites are excreted in human milk. The excretion of mebeverine in milk has not been studied in animals. Mebeverine should not be used during breastfeeding

Renal Impairment

• No dose adjustment recommended

Hepatic Impairment

• No dose adjustment recommended

Elderly

• No dose adjustment recommended

Porphyria Information

• Probably not porphyrinogenic (PNP)

Drugs in Sport

• Permitted - No warnings

Skin and Subcutaneous Tissue Disorders

• Urticaria
• Angioedema
• Facial oedema
• Exanthema

Immune, Blood and Lymphatic System Disorders

• Anaphylactic reactions

No information available

None routine

Mebeverine is a musculotropic antispasmodic. It acts directly on the smooth muscle of the gastrointestinal tract, without affecting normal gut motility. Mechanisms of action involve a decrease in ion channel permeabilities, blockade of noradrenaline reuptake, a local anesthetic effect, changes in water absorption, antimuscarinic activity, and a phosphodiesterase inhibitory effect.

Tablet 135mg

• Bevispas (Pharmacare)
• Colofac (Abbott) originator
• Mylan Mebeverine (Mylan)
• Sandoz Mebeverine (Sandoz)