neobookRx
DrugsLevel 4 LocalisationN/AOTHEML

Mephenesin

Muscle relaxantNot available as a single agent preparation

Cautions

Contraindications

  • Hypersensitivity to the active ingredient or to any of its excipients 
  • Hepatic impairment 

Cautions

  • Pregnancy 
  • Breastfeeding 
  • Renal impairment 
  • Elderly 
  • May impair ability to drive and operate machinery 

Special populations

Pregnancy

  • Caution
  • Use of mephenesin during pregnancy is not recommended as available evidence is inadequate to determine foetal risk

Breastfeeding

  • Caution; not recommended
  • Use of mephenesin during breastfeeding is not recommended as available evidence is inadequate to determine infant risk

Renal Impairment

Hepatic Impairment

Elderly

Porphyria Information

Adverse reactions

Central Nervous System Disorders

  • Dizziness 
  • Drowsiness 

Gastrointestinal Disorders

  • Nausea and vomiting

Skin and Subcutaneous Tissue Disorders

  • Urticaria
  • Pruritus
  • Rash

Immune, Blood and Lymphatic System Disorders

  • Fever

Sensory Disorders

  • Blurred vision

Interactions

No information available

Mechanism of action

Mephenesin is a centrally acting skeletal muscle relaxant used for the symptomatic treatment of painful muscle spasm. Its clinical usefulness is limited by its short duration of action and does not relieve the spasticity associated with chronic neurological disorders.

Dosage forms

  • Other

References

1. Pharmacologist: Dr Ahmed Abulfathi 1.1 Martindale 1.2 PubChem 1.3 Sinha JN et al. Jap. J. Pharmac. 1118, 48-53 (1968) 1.4 Spasmend PIL 2. NAPOS: The Drug Database for Acute Porphyria: Mephenesin; Accessed online 01 Apr 2019 [http://www.drugs-porphyria.org/languages/UnitedKingdom/s3.php?l=gbr&atc_code=M03BX06]

Medical aid coverage

data not yet integrated
Discovery Health
not yet integrated
  • Comprehensive Series—
  • Executive Plan—
  • KeyCare Series—
  • Priority Series—
  • Saver Series—

Formulary scraper pending — coverage tier, co-pay and authorisation requirements will appear here once data is ingested.

Bonitas Medical Fund
not yet integrated
  • BonClassic—
  • BonComprehensive—
  • BonEssential—
  • BonFit Select—
  • BonSave—
  • BonStart—

Formulary scraper pending — coverage tier, co-pay and authorisation requirements will appear here once data is ingested.

GEMS — Government Employees Medical Scheme
not yet integrated
  • Beryl—
  • Emerald—
  • Onyx—
  • Ruby—
  • Sapphire—
  • Tanzanite One—

Formulary scraper pending — coverage tier, co-pay and authorisation requirements will appear here once data is ingested.

POLMED — Police Medical Aid Scheme
not yet integrated
  • Aquarium Option—
  • Efficiency Option—
  • Marine Option—

Formulary scraper pending — coverage tier, co-pay and authorisation requirements will appear here once data is ingested.

NeoHealth® ID 15412 · updated 7/12/2022