Mepyramine (oral)

Contraindications

• Hypersensitivity to the active ingredient or any of the excipients
• Severe hepatic impairment

Cautions 

• Pregnancy 
• Breastfeeding
• Renal impairment 
• Mild to moderate hepatic impairment 
• Elderly
• Children
• Prostatic hypertrophy
• Angle-closure glaucoma
• Porphyria
• May impair ability to drive and operate machinery

Pregnancy

• Caution 
• Use of mepyramine during pregnancy is not recommended, since its safety profile is not adequately determined and foetal risk cannot be excluded
• Safer alternatives should be considered

Breastfeeding

• Caution 
• Small occasional doses of mepyramine are probably acceptable; however, large doses or more prolonged use may cause effects in the infant or decrease lactation, particularly in combination with sympathomimetics
• Non-sedating anti-histamines are the preferred option during breastfeeding

Renal Impairment

• Caution; no information available

Hepatic Impairment

• Mild to moderate: Caution; no information available
• Severe: Contraindicated

Elderly

• Caution; no dose adjustment recommended

Central Nervous System Disorders

• Sedation
• Drowsiness
• Excitement
• Euphoria
• Insomnia
• Nervousness
• Tremor

Cardiovascular Disorders

• Palpitations
• Hypotension

Gastrointestinal Disorders

• Nausea and vomiting
• Anorexia
• Abdominal discomfort
• Constipation
• Diarrhoea
• Dry mouth

Skin and Subcutaneous Tissue Disorders

• Photosensitivity
• Rash
• Contact dermatitis

Immune, Blood and Lymphatic System Disorders

• Agranulocytosis
• Leucopaenia
• Haemolytic anaemia
• Thrombocytopaenia

Sensory Disorders

• Blurred vision

• Monoamine oxidase inhibitors
• Anticholinergic agents
• Central nervous system depressants

Mepyramine reversibly competes for histamine-1 receptors in target tissues, thereby preventing the action of histamine. Mepyramine is a 1st generation antihistamine that has sedative, mild anticholinergic and local anaesthetic activity.