Mesterolone

Registered South African indications:

• Symptoms of androgen deficiency in middle and old aged men
• Prepubertal hypogonadism
• Infertility

Contraindications

• Hypersensitivity to the active ingredient or any of its excipients
• Patients with carcinoma of the prostate, androgen therapy of any kind, including the use of mesterolone is contraindicated

Cautions

• Pregnancy
• Renal impairment
• Hepatic impairment

Forms avail. in SA and covered in this monograph: tab 

Symptoms of androgen deficiency due to hypogonadism in middle and old aged men

• Oral (tab): 25-100mg/day, in divided doses

Infertility
-Oligozoospermia

• Oral (tab): 25mg, 8-12hrly; Treatment duration: 90 days

See additional prescribing point

Specialist Paediatric Endocrinologist initiated

Pregnancy

• Not indicated for use

Breastfeeding

• Not indicated for use

Renal Impairment

• Caution; no information available

Hepatic Impairment

• Caution; no information available

Elderly

• No dose adjustment recommended

Endocrine and Metabolic Disorders

• Frequent or persistent erections

No information available

None routine

Mesterolone is not aromatised to oestrogen, therefore does not cause gynecomastia. However, because it is an oral drug its bioavailability is very variable and unpredictable

Mesterolone balances a deficiency of androgen formation which begins to fall gradually with increasing age. Therefore, it is suitable for treatment of all conditions caused by deficient endogenous androgen formation. In the recommended therapeutic dosage it will not impair spermatogenesis.

Tablet 25mg

• Proviron (Bayer) originator