Methylrosanilinium Chloride
Indications
These indications are based on manufacturer information for both originator and generic products. For product specific registered indications, please refer to product specific manufacturer information
Registered South African indications:
- Bacterial skin infections
- Superficial fungal infections
Cautions
Contraindications
- Hypersensitivity to the active ingredient or any of its excipients
- Contact with eyes
- Application to mucous membranes
- Application to ulcerative lesions
Cautions
- Pregnancy
- Breastfeeding
- Porphyria
Adult dosage
Forms avail. in SA and covered in this monograph: sol
- Topical (sol): Apply small quantity to affected area(s), 12-24hrly
Paediatric dosage
Paed. forms avail. in SA and covered in this monograph: sol
- See adult dosage
Special populations
Pregnancy
- Use is not recommended during pregnancy, safer alternatives for topical skin infections are available
Breastfeeding
- Caution; not recommended
- Due to the potential for serious adverse reactions in the nursing infant, breastfeeding is not recommended, safer alternatives for topical skin infections are available
Renal Impairment
Hepatic Impairment
Elderly
Porphyria Information
Drugs in Sport
- Non-regulated product: Authorities caution athletes against the risk of using these products
Adverse reactions
Respiratory Disorders
- Epistaxis
- Laryngitis
- Tracheitis
Gastrointestinal Disorders
- Oesophagitis
- Gastrointestinal irritation
- Mucous membrane ulceration
Genitourinary Disorders
- Hemorrhagic cystitis
Skin and Subcutaneous Tissue Disorders
- Localized burning
- Allergic contact dermatitis
- Local skin necrosis
- Skin discoloration
- Skin vesicle
- Local irritation
- Tissue necrosis at injection site
Immune, Blood and Lymphatic System Disorders
- Hypersensitivity reaction
- Acute attacks of porphyria
Sensory Disorders
- Keratoconjunctivitis
Interactions
- Sodium picosulphate
- BCG (intravesical)
- BCG (immunization)
Monitoring
None routine
Mechanism of action
Methylrosanilinium chloride is a triphenylmethane antiseptic/germicide effective against some vegetative gram-positive bacteria and some yeast, it is much less effective against gram-negative bacteria and is ineffective against acid-fast bacteria.
Spectrum of activity: Gram-positive bacteria (especially Staphylococcus sp); yeasts (mostly Candida sp)
Dosage forms
- Solution
Formulation
Methylrosanilinium chloride is available in several formulations. Please consult your pharmacy for the various products available.
References
1. U2D: Gentian violet: Drug Information; Uptodate; Downloaded online 12 October 2018 https://www.uptodate.com/contents/gentian-violet-drug-information?search=gentian%20violet&source=search_result&selectedTitle=1~20&usage_type=default&display_rank=1 2. Pharmacologist Pharmacologist's References: • Micromedex medicine solutions. • Martindale the complete drug reference, 36th edition. • Rosenkranz HS, Carr HS. Possible hazard in use of gentian violet. BMJ 1971; 3: 702–3. • Walsh C, Walsh A. Haemorrhagic cystitis due to gentian violet. BMJ 1986; 293: 732. • Gutteridge WE: Existing chemotherapy and its limitations. Br Med Bull 1985; 41:162-168. • Breastfeeding and Maternal Medication. World Health Organization, Geneva, Switzerland, 2002. 3. NAPOS The Drug Database for Acute Porphyria: Gentian violet; Accessed online 15 October 2018 http://www.drugs-porphyria.org/languages/UnitedKingdom/s1.php?l=gbr 4. South African Institute for Drug-Free Sport: Gentian violet; Accessed online 15 October 2018 http://www.drugfreesport.org.za/online-medication-check/ **No SPC available
Medical aid coverage
data not yet integrated- Comprehensive Series—
- Executive Plan—
- KeyCare Series—
- Priority Series—
- Saver Series—
Formulary scraper pending — coverage tier, co-pay and authorisation requirements will appear here once data is ingested.
- BonClassic—
- BonComprehensive—
- BonEssential—
- BonFit Select—
- BonSave—
- BonStart—
Formulary scraper pending — coverage tier, co-pay and authorisation requirements will appear here once data is ingested.
- Beryl—
- Emerald—
- Onyx—
- Ruby—
- Sapphire—
- Tanzanite One—
Formulary scraper pending — coverage tier, co-pay and authorisation requirements will appear here once data is ingested.
- Aquarium Option—
- Efficiency Option—
- Marine Option—
Formulary scraper pending — coverage tier, co-pay and authorisation requirements will appear here once data is ingested.