Orciprenaline

Contraindications

• Hypersensitivity to the active ingredient or any of its excipients
• Tachyarrhythmias

Cautions

• Pregnancy
• Breastfeeding
• Renal impairment
• Hepatic impairment
• Elderly
• Children
• Cardiovascular disease
• Hypertension
• Hyperthyroidism  
• Diabetes mellitus

Pregnancy

• Caution
• In animal studies, adverse reactions have been observed. Orciprenaline should only be considered during pregnancy if the potential benefit justifies the potential risk to the foetus

Breastfeeding

• Caution; no information available
• No published data is available for the use of orciprenaline during breastfeeding. However, data from a related agent, terbutaline indicate that very little is expected to be excreted into breast milk

Renal Impairment

• Caution; no dose adjustment recommended
  Dose adjustment may be required depending on the degree of renal impairment
  Recommendation: Consult specialist on guidance on dose adjustments

Hepatic Impairment

• Caution; dose adjustment recommended
  Dose adjustment may be required depending on the degree of hepatic impairment
  Recommendation: Consult specialist on guidance on dose adjustments

Elderly

• Caution; no dose adjustment recommended

Porphyria Information

• Not yet classified (NC)

Central Nervous System Disorders

• Nervousness
• Tremor  
• Headache
• Dizziness
• Psychosis
• Insomnia
• Emotional lability

Cardiovascular Disorders

• Tachycardia
• Flushing
• Palpitations

Respiratory Disorders

• Bronchospasm

Gastrointestinal Disorders

• Nausea and vomiting
• Bowel distension

• Tricyclic antidepressants
• Beta-blockers
• Monoamine oxidase inhibitors  
• Xanthine derivatives
• Sympathomimetic agents

Orciprenaline is a direct-acting sympathomimetic agent with mainly beta-adrenoceptor stimulant activity. It has actions similar to salbutamol but is less selective for β2 adrenoreceptors.