Orphenadrine Citrate

Registered South African indications:

• Conditions involving skeletal muscle spasm
  - Such as low back pain and torticollis and also those resulting from trauma such as whiplash injury

Contraindications

South African recommendations

• Pregnancy
• Glaucoma 
• Tachycardia 
• Urinary retention 
• Achalasia 
• Prostatic hypertrophy 
• Bladder neck obstruction 
• Myasthenia gravis 
• Peptic ulcer stenosing 
• Pyloric or duodenal obstruction 
• Porphyria 

Cautions

• Breastfeeding
• Hepatic impairment
• Renal impairment
• Elderly (particularly males)
• Micturition difficulties
• Cardiac insufficiency
• Tachycardia
• Heart failure
• Thyrotoxicosis
• Abrupt discontinuation

Forms avail. in SA and covered in this monograph: tab

Dosages below include:

• South African registered indications and dosages

South African registered indications and dosages

Conditions involving skeletal muscle spasm
- Such as low back pain and torticollis and also those resulting from trauma such as whiplash injury

• Oral (tab): 100mg, 8-12hrly with water

No information available for children in South Africa

Pregnancy

• Contraindicated
• Safe use of orphenadrine has not been established with respect to adverse effects on foetal development
• Orphenadrine citrate should therefore be used in women of childbearing potential and particularly during early pregnancy only when in the judgment of the physician the potential benefits outweigh the possible hazards

Breastfeeding

• Caution; no information available

Renal Impairment

• Caution; no dose adjustment recommended

Hepatic Impairment

• Caution; no dose adjustment recommended

Elderly

• Caution; no dose adjustment recommended

Porphyria Information

• Porphyrinogenic (P)

Drugs in Sport

• Permitted - No warnings

Central Nervous System Disorders

• Dizziness
• Sedation
• Confusion
• Nervousness
• Hallucinations
• Convulsions
• Insomnia
• Euphoria
• Memory disturbances
• Co-ordination disturbances
• Restlessness

Cardiovascular Disorders

• Tachycardia

Gastrointestinal Disorders

• Dry mouth
• Gastrointestinal disturbances
• Nausea
• Constipation

Genitourinary Disorders

• Urinary retention

Immune System Disorder

• Hypersensitivity reaction

Sensory Disorders

• Accommodation disorders

• Antimuscarinic agents

None routine

Orphenadrine citrate is a centrally acting anticholinergic. It relaxes skeletal muscle spasms without affecting normal muscle tone. 

Tablet 100mg

• Norflex (iNova Pharma) originator