Oxybuprocaine
Indications
Registered South African indications:
- Ophthalmic pain
Cautions
Contraindications
- Hypersensitivity to the active ingredient or any of its excipients
Cautions
- Pregnancy
- Breastfeeding
- Renal impairment
- Hepatic impairment
Adult dosage
Forms avail. in SA and covered in this monograph: opd
Ophthalmic pain
- Ophthalmic (opd): 1-3 drops into affected eye(s), administered at 90 second intervals
Paediatric dosage
See adult dosage
Special populations
Pregnancy
- Caution
- Oxybuprocaine should not be used in pregnancy unless the benefits clearly outweigh the possible risks to the mother and foetus
Breastfeeding
- Caution
- Oxybuprocaine should not be used by breastfeeding mothers unless the benefits clearly outweigh the possible risks to the mother and infant
Renal Impairment
Hepatic Impairment
Elderly
Porphyria Information
Drugs in Sport
- Permitted - No warnings
Adverse reactions
Sensory Disorders
- Transient stinging
- Blurring of vision
- Corneal damage
Interactions
No information available
Monitoring
None routine
Mechanism of action
Oxybuprocaine hydrochloride is used as a local anaesthetic. It reversibly blocks the propagation and conduction of nerve impulses along nerve axons.
Dosage forms
- Eye drops
Formulation
Eye drop (per 100ml) 0.4g
- Novesin Wander 0.4% (Adcock) originator
- Minims Oxybuprocaine hcl 0.4% (was Min benoxinate hcl) (Soflens) originator
References
1. SAMF_12th Edition_Page 584 2. SmPC: Minims Oxybuprocaine Hydrochloride 0.4% w/v, Bausch & Lomb U.K Limited: Last updated on eMC: 16 Jul 2012; Downloaded online 16 Aug 2018 [https://www.medicines.org.uk/emc/medicine/417 ] 3. https://drive.google.com/drive/folders/0B27NqM_vidrmV0VrcGJCeHAtVXc (26/08/1970_Soflens_Minims Oxybuprocaine Hydrochloride 0.4%_eye drops) 4. NAPOS The Drug Database for Acute Porphyria: S01HA02 Oxybuprocaine; Accessed online 10 Feb 2019 [http://www.drugs-porphyria.org/languages/UnitedKingdom/s3.php?atc_code=S01HA02&l=gbr] 5. South African Institute for Drug-Free Sport: Novesin Wander; Accessed online 10 Feb 2019 [http://www.drugfreesport.org.za/online-medication-check/]
Brands & products
2 products · stale NAPPI snapshot · refreshed 5/28/2026 · 159 days oldOpmGeneric· 1 product
from R29.80/unit| Product | Strength | Pack | Sched | SEP | Unit | Disp fee | NAPPI |
|---|---|---|---|---|---|---|---|
| Min oxybuprocaine hcl (was Min benoxinat | - g/100ml | 0 | S4 | R595.94 | R29.80 | R172.13 | 743526015 |
dropsGeneric· 1 product
from R89.27/unit| Product | Strength | Pack | Sched | SEP | Unit | Disp fee | NAPPI |
|---|---|---|---|---|---|---|---|
| Novesin wander 3ml | - g/100ml | 3 | S4 | R267.81 | R89.27 | R98.88 | 748188002 |
- Novesin Wander 0.4%
- Minims Oxybuprocaine hcl 0.4% (was Min benoxinate hcl)
Medical aid coverage
data not yet integrated- Comprehensive Series—
- Executive Plan—
- KeyCare Series—
- Priority Series—
- Saver Series—
Formulary scraper pending — coverage tier, co-pay and authorisation requirements will appear here once data is ingested.
- BonClassic—
- BonComprehensive—
- BonEssential—
- BonFit Select—
- BonSave—
- BonStart—
Formulary scraper pending — coverage tier, co-pay and authorisation requirements will appear here once data is ingested.
- Beryl—
- Emerald—
- Onyx—
- Ruby—
- Sapphire—
- Tanzanite One—
Formulary scraper pending — coverage tier, co-pay and authorisation requirements will appear here once data is ingested.
- Aquarium Option—
- Efficiency Option—
- Marine Option—
Formulary scraper pending — coverage tier, co-pay and authorisation requirements will appear here once data is ingested.