Oxymetazoline/ Zinc Sulphate

Registered South African indications:

• Colds
• Allergic rhinitis
• Sinusitis
• Hayfever

Contraindications

• Hypersensitivity to the active ingredient or any of its excipients
• Do not administer to children under 6 years of age
• Acute porphyria

Cautions

Caution in the following patient groups

• Pregnancy
• Breastfeeding
• Renal impairment
• Hepatic impairment
• Elderly

Prolonged use

• May cause rebound congestion and drug-induced rhinitis

Forms avail. in SA and covered in this monograph: nas

Colds
Allergic rhinitis
Sinusitis
Hayfever
- Associated with acute nasal congestion

Oxymetazoline/ Zinc sulphate
0.5/0.015 (mg/ml)

• Nasal (nas): Apply 1 spray per nostril, 8-24hrly

Hold head upright, place the tip of the spray in the nostril, squeeze the plastic bottle quickly and firmly while breathing in, at the same time closing the other nostril

Not established for use in children below 6 years

Recommendations for this combination product as per highest risk category when comparing individual active ingredients

Pregnancy

• FDA Pregnancy Category Not Rated (NR) (Oxymetazoline)

Breastfeeding

• Caution; not recommended (Oxymetazoline)

Renal Impairment

• Caution; no information available (Zinc sulphate)

Hepatic Impairment

• Caution; no information available (Zinc sulphate)

Elderly

• Caution; no information available (Zinc sulphate)

Combination products may have additional pharmacological effects not accounted for by the action of the individual ingredients

Oxymetazoline
Central Nervous System Disorders

• Headaches
• Dizziness
• Insomnia
• Nervousness
• Tremor
• Anxiety

Cardiovascular Disorders

• Palpitations
• Hypertension
• Tachycardia

Respiratory Disorders

• Sneezing
• Dry mouth and throat
• Rebound nasal congestion

Gastrointestinal Disorders

• Nausea

Skin and Subcutaneous Tissue Disorders

• Localised burning 
• Contact dermatitis

Zinc sulphate
Gastrointestinal Disorders

• Dry mouth
• Dry throat 

Sensory Disorders

• Local irritant effect

Combination products may have additional pharmacological effects not accounted for by the action of the individual ingredients

Oxymetazoline

• Monoamine oxidase inhibitors 
• Adrenergic neurone-blocking agents 
• Centrally acting antiadrenergic agents 
• Antihypertensives
• Appetite suppressants
• Amphetamine-like psychostimulants 
• Antiparkinson agents
• Cardiac glycosides 
• Ergot alkaloids 

Zinc sulphate

• No information available

None routine

Oxymetazoline
Oxymetazoline is an alpha-adrenergic agonist that acts on nasal and ophthalmic vasculature to produce vasoconstriction thus relieving symptoms of congestion. 

Zinc sulphate
As a nasal spray, the astringent property of zinc sulphate makes it suitable to be used in the treatment of common cold. 

COMBINATION PREPARATIONS

Oxymetazoline/ Zinc sulfate

Nasal spray (per ml) 0.5g/0.015mg

• Nazene Z (Adcock)