Panthenol

Contraindications

• Hypersensitivity to the active ingredient or any of its excipients
• Haemophilia
• Ileus due to mechanical obstruction
• Children < 2 years

Cautions

• Pregnancy
• Breastfeeding
• Renal impairment
• Hepatic impairment
• Elderly

Pregnancy

• Caution
• Animal reproduction studies have not been conducted. Panthenol should be given only if the potential benefit justifies the potential risk to the foetus

Breastfeeding

• Caution
• Infant risk cannot be ruled out. Available evidence and /or expert consensus in inconclusive or inadequate to determine infant risk

Renal Impairment

• Caution; no information available 
  No data are available to determine risk. Use of alternative agents with known safety profile is recommended

Hepatic Impairment

• Caution; no information available 
  No data are available to determine risk. Use of alternative agents with known safety profile is recommended

Elderly

• Caution; no dose adjustment recommended 

Porphyria Information

• Not yet classified (NC)

Gastrointestinal Disorders

• Colic
• Vomiting
• Diarrhoea

Skin and Subcutaneous Tissue Disorders

• Itching
• Tingling
• Urticaria
• Generalized dermatitis

Immune, Blood and Lymphatic System Disorders

• Hypersensitivity

No information available

Panthenol is a racemic mixture of the dextrorotatory and laevorotatory isomers of panthenol. Dexpanthenol is the alcoholic analog of the B-complex vitamin d-pantothenic acid and is a precursor of coenzyme A, which is necessary for acetylation reactions and the synthesis of acetylcholine. Panthenol is postulated to enhance the effect of acetylcholine.