Phenazone
Indications
Registered South African indications:
- Pain
- Inflammation
Cautions
Contraindications
- Hypersensitivity to the active ingredient and any of its excipients
- Family history of porphyria
Cautions
- Perforated ear drum
Adult dosage
Forms avail. in SA and covered in this monograph: drops
Otalgia
Ear inflammation
- Otic: 5-10 drops, 2hrly into affected ear
See additional prescribing points for administration directions
Paediatric dosage
No information available
Special populations
Pregnancy
Breastfeeding
Renal Impairment
Hepatic Impairment
Elderly
Porphyria Information
South African recommendations
- Family history of porphyria: Contraindicated
Recommendations in other jurisdictions
Drugs in Sport
- Permitted - No warnings
Adverse reactions
Skin and Subcutaneous Tissue Disorders
- Skin eruptions
Immune disorders
- Hypersensitivity reactions
Interactions
No information available
Monitoring
None routine
Prescribing points
Administration directions
- Hold the bottle in your hand for 1 or 2 minutes to warm the solution
- Place the prescribed number of drops into your ear
- Be careful not to touch the tip to your ear, fingers, or any other surface
- Moisten a small piece of cotton with the drops and insert into the outer ear
-
Lightly plug ear with cotton wool
Mechanism of action
Thought to act primarily in the central nervous system, increasing the pain threshold by inhibiting cyclooxygenase, involved in prostaglandin (PG) synthesis.
Dosage forms
- Ear drops
Formulation
Drops (per 15ml) 750mg
- Aurone (Pharmacare)
COMBINATION PREPARATIONS
Benzocaine/ Chlorbutol/ Phenazone/ Glycerol
Drops (per 15ml) 150mg/150mg/750mg
- Aurone Forte (Pharmacare)
Benzocaine/ Glycerine/ Phenazone
Drops (per ml) 0,01g/1,185g/0,05g
- Otised (Adcock) originator
Benzocaine/ Chlorbutol/ Phenazone
Drops 1%/1%/5%
- Otalgon (Gulf Drug)
Drops (per 20ml) 0,2g/0,2g/1g
- Oti-Ezze Ear Drops (Pharma Q)
Benzocaine/ Carbamide/ Phenazone/ Sulfacetamide
Drops 10mg/120mg/50mg/100mg
- Covancaine (Adcock) originator
Phenazone/ Procaine/ Potassium
Drops 50mg/10mg/1mg
- Universal earache drops (Acino Pharma) originator
Benzocaine/ Diodohydroxyquinoline/ Ephedrine/ Phenazone
Drops (per 10 grams) 140mg/10mg/100mg/550mg
- Otophen Forte (Adcock) originator
References
1. PI - Aurone ear - Aspen pharmacare - Date of the most recent amendment - January 1975 - accessed on SAHPRA 31 October 2024.pdf [https://drive.google.com/drive/u/0/folders/1DMEIttFRefpEHHY2Badm4HpjAEdPRCTU] [https://medsinfoportal.sahpra.org.za/pi/611ce6d22a52a2c1ab489751e865d4d2.pdf] 2. No SPC available 3. No info in SAMF 4. http://www.nlm.nih.gov/medlineplus/druginfo/meds/a607073.html 5. https://www.hpra.ie/img/uploaded/swedocuments/ie-mockup-pl-13022009-2140030-21112013112835-635206301169790000.pdf 6. https://www.drugbank.ca/drugs/DB01435
Brands & products
12 products · stale NAPPI snapshot · refreshed 5/29/2026 · 158 days oldsyrupGeneric· 1 product
from R0.84/unit| Product | Strength | Pack | Sched | SEP | Unit | Disp fee | NAPPI |
|---|---|---|---|---|---|---|---|
| Ilvico | - | 150 | S2 | R126.02 | R0.84 | R55.48 | 732400007 |
dropsGeneric· 9 products
from R1.38/unit| Product | Strength | Pack | Sched | SEP | Unit | Disp fee | NAPPI |
|---|---|---|---|---|---|---|---|
| Famotic Ear Drops | - g/25g | 500 | S1 | R690.25 | R1.38 | R186.01 | 840017006 |
| Famotic Ear Drops | - g/25g | 20 | S1 | R48.99 | R2.45 | R28.83 | 844009003 |
| Universal ear 15ml | 50 mg | 15 | S2 | R62.54 | R4.17 | R33.52 | 773859004 |
| Otalgon (plastic bottle) 15ml | 5 %m/v | 15 | S2 | R66.06 | R4.40 | R34.74 | 704127001 |
| Oti-ezze 20ml | 1 g/20ml | 20 | S2 | R99.65 | R4.98 | R46.36 | 817023003 |
| Otophen Forte | 140 mg/10g | 10 | S2 | R71.29 | R7.13 | R36.55 | 839981007 |
| Otalgon | 5 %m/v | 15 | S2 | R113.13 | R7.54 | R51.03 | 3008764001 |
| Aurone 15ml | 750 mg/15ml | 15 | S2 | R135.78 | R9.05 | R58.86 | 705780007 |
| Aurone forte 15ml | 150 mg/15ml | 15 | S2 | R142.07 | R9.47 | R61.04 | 705799018 |
tabletGeneric· 1 product
from R5.88/unit| Product | Strength | Pack | Sched | SEP | Unit | Disp fee | NAPPI |
|---|---|---|---|---|---|---|---|
| Ilvico | 20 mg | 24 | S2 | R141.16 | R5.88 | R60.72 | 732419018 |
liquidGeneric· 1 product
from R6.63/unit| Product | Strength | Pack | Sched | SEP | Unit | Disp fee | NAPPI |
|---|---|---|---|---|---|---|---|
| Aurasept | 10 mg/ml | 15 | S2 | R99.48 | R6.63 | R46.30 | 705632009 |
- Aurone
Medical aid coverage
data not yet integrated- Comprehensive Series—
- Executive Plan—
- KeyCare Series—
- Priority Series—
- Saver Series—
Formulary scraper pending — coverage tier, co-pay and authorisation requirements will appear here once data is ingested.
- BonClassic—
- BonComprehensive—
- BonEssential—
- BonFit Select—
- BonSave—
- BonStart—
Formulary scraper pending — coverage tier, co-pay and authorisation requirements will appear here once data is ingested.
- Beryl—
- Emerald—
- Onyx—
- Ruby—
- Sapphire—
- Tanzanite One—
Formulary scraper pending — coverage tier, co-pay and authorisation requirements will appear here once data is ingested.
- Aquarium Option—
- Efficiency Option—
- Marine Option—
Formulary scraper pending — coverage tier, co-pay and authorisation requirements will appear here once data is ingested.