Phenyltoloxamine (oral)

Contraindications

• Hypersensitivity to the active ingredient or any of its excipients

Cautions

• Hypersensitivity to other antihistamines, especially ethanolamine-type agents
• Pregnancy
• Breastfeeding
• Renal impairment
• Hepatic impairment
• Elderly
• Prostatic hypertrophy
• Urinary retention
• Bladder neck obstruction
• Closed angle glaucoma
• Asthma

Pregnancy

• Caution
• Available evidence is inconclusive or inadequate to determine fetal risk. Weigh potential benefit against risk, while considering alternatives where fetal risk is more established. Consider safer alternatives

Breastfeeding

• Caution; not recommended
• It is unclear if phenyltoloxamine is excreted in breast milk and harm to breastfed infant cannot be ruled out. Consider using alternatives and weigh the benefit and potential risk to infant

Renal Impairment

• Caution; no information available 
  Consider safer alternatives

Hepatic Impairment

• Caution; no information available 
  Consider safer alternatives

Elderly

• Caution; no information available 
  Consider safer alternatives

Central Nervous System Disorders

• Drowsiness
• Dizziness
• Euphoria
• Faintness
• Tiredness

Cardiovascular Disorders

• Tachycardia
• High degree heart block

Skin and Subcutaneous Tissue Disorders

• Diaphoresis

Sensory Disorders

• Blurred vision

No information available

Phenyltoloxamine is an ethanolamine-type antihistamine which possesses typical H1-histamine antagonist properties. It available only in combination preparations for the treatment of coughs, cold, allergies. In addition to antihistaminic activity, it is considered to have analgesic properties. It has been suggested that the analgesic effects of antihistamines are related to modulation serotonergic and histaminergic pathways that may be involved in nociception.