Piperonyl Butoxide (topical)

Contraindications

• Hypersensitivity to the active ingredient or any of its excipients
• Children <30 months

Cautions

• Pregnancy
• Breastfeeding
• Renal impairment
• Hepatic impairment
• Elderly
• Exposure to eyes, mucous membrane or denuded skin
• Flammable

Pregnancy

• Caution
• Risk unclear

Breastfeeding

• Caution; no information available
• No data available. Infant risk cannot be ruled out

Renal Impairment

• Caution; no information available

Hepatic Impairment

• Caution; no information available

Elderly

• Caution; no information available

Central Nervous System Disorders

• Seizures
• Central nervous system depression

Respiratory Disorders

• Respiratory tract irritation

Gastrointestinal Disorders

• Nausea and vomiting
• Abdominal cramps
• Diarrhoea

Skin and Subcutaneous Tissue Disorders

• Contact allergic reaction
• Burning
• Pruritis

Sensory Disorders

• Ocular irritation

No information available

Piperonyl butoxide (PBO) is an insecticide synergist, which acts by protecting the co-applied insecticide (e.g. pyrethrins, pyrethroids and other pesticides) from metabolic attack thus allowing them to reach their biochemical targets. As a result of inhibiting oxidative processes in living organisms, PBO has intrinsic toxic potential to arthropods such as lice, ticks, mosquitoes etc.