Podophyllin/ Salicylic Acid/ Benzoin Tincture

Registered South African indications:

• Warts
• Corns
• Calluses

Combination products may have additional pharmacological effects not accounted for by the action of the individual ingredients

Contraindications

• Hypersensitivity to the active ingredients or any of the excipients in this combination product

Cautions

Caution in the following patient groups

• Pregnancy
• Breastfeeding

Special precautions

• Podophyllin/salicylic acid/benzoin tincture is extremely caustic to healthy skin and care must be exercised to apply only on the affected area
• If any pain or inflammation is experienced during treatment, application must be stopped
• Recommendation is to use under medical supervision

Forms avail. in SA and covered in this monograph: liq

Topical treatment of warts, genital warts, corns and callouses

Podophyllin/ Salicylic acid/ Benzoin tincture
0.75/0.5/4.2 (g/5ml)

• Topical (liq): Apply to affected area at night; Treatment duration: 4-5 days

Do not apply to healthy skin

Discontinue application if pain or inflammation occur

Liquid to be washed off in the morning

Repeat after 1 week if necessary

No information available

Recommendations for this combination product as per highest risk category when comparing individual active ingredients

Pregnancy

• Caution; no information available

Breastfeeding

• Caution; not recommended (Podophyllin, Salicylic acid)

Renal Impairment

• No dose adjustment recommended (Podophyllin, Salicylic acid)

Hepatic Impairment

• No dose adjustment recommended (Podophyllin, Salicylic acid)

Elderly

• No dose adjustment recommended (Podophyllin, Salicylic acid)

Combination products may have additional pharmacological effects not accounted for by the action of the individual ingredients

Podophyllin
Central Nervous System Disorders

• Polyneuropathy
• Parasthesia

Gastrointestinal Disorders

• Paralytic ileus

Immune, Blood and Lymphatic System Disorders

• Leukopaenia
• Thrombocytopaenia
• Fever

Skin and Subcutaneous Tissue Disorders

• Skin erosion
• Application site irritation

Salicylic acid
Central Nervous System Disorders

• Confusion
• Dizziness
• Headache

Respiratory Disorders

• Hyperventilation

Skin and Subcutaneous Tissue Disorders

• Localised irritation
• Desquamation
• Exfoliation of the skin

Sensory Disorders

• Tinnitus

Combination products may have additional pharmacological effects not accounted for by the action of the individual ingredients

Podophyllin

• Steroids

Salicylic acid

• No information available

None routine

Podophyllin
Podophyllotoxin is a metaphase inhibitor in dividing cells binding to at least one binding site on tubulin. Binding prevents tubulin polymerisation required for microtubule assembly. At higher concentrations podophyllotoxin also inhibits nucleoside transport through the cell membrane. The chemotherapeutic action of podophyllotoxin is assumed to be due to inhibition of growth and the ability to invade the tissue of the viral infected cells.

Salicylic acid
Salicylic acid has been used extensively in dermatological therapy for its keratolytic properties. When applied topically, and in high enough concentrations, salicylic acid acts by achieving a slow, painless destruction of the thickened stratum corneum. It softens and destroys the thickened stratum corneum of the affected tissue by reducing the adhesiveness of the corneocytes while causing the cornified epithelium to swell, soften, macerate and finally desquamate. In the treatment of warts and verrucas, a mild inflammatory reaction, which may render the virus more prone to immunologic attack, may assist resolution of the condition.

Benzoin tincture
This ingredient has no pharmacological effect.

COMBINATION PREPARATIONS

Podophyllin/ Salicylic acid/ Benzoin tinct

Liquid (per 5ml) 0.75g/0.5g/4.2g

• Wart magic liquid (Thebe)