Potassium Sodium Hydrogen Citrate

Registered South African indications:

• Urinary tract calculi
• Alkalinise the urine

Contraindications

• Hypersensitivity to the active ingredient or any of its excipients
• Renal impairment
• Hepatic impairment
• Cardiac failure
• Hypernatraemia
• Hyperkalaemia
• Alkalosis
• Coadministration with potassium sparing diuretics

Cautions

• Pregnancy
• Breastfeeding
• Elderly
• Adrenal insufficiency
• Sodium controlled diet

Forms avail. in SA and covered in this monograph: gra

Uric acid caculi
- To dissolve uric acid calculi in the urinary tract and to prevent further stone formation
To alkalinise the urine during treatment with uricosuric agents and during cytostatic therapy

• Oral (gra): The dose is adjusted according to pH value of the urine; Maintenance: 10g/day

The granules should be dissolved, by stirring in half a glass of water or fruit juice and taken, preferably after meals

Check the pH value of the urine before each dose

The pH value shows the response to the previous dose

See additional prescribing points 

No information available

Pregnancy

• FDA Pregnancy Category Not Rated (NR)

Breastfeeding

• Caution

Renal Impairment

• Contraindicated

Hepatic Impairment

• Contraindicated

Elderly

• Caution; no information available

Drugs in Sport

• Permitted - No warning

Gastrointestinal Disorders

• Gastric irritation

Endocrine and Metabolic Disorders

• Metabolic alkalosis

• Ciprofloxacin
• Norfloxacin 
• Ofloxacin
• Salicylates
• Urinary antiseptics
• Antacids
• Potassium sparing diuretics

Urine pH

Reference pH ranges

Uric acid calculi

• The pH should be stabilised with within the desired range 6.2-6.8

During treatment uricosuric agents

• The pH should be stabilised between 6.2-6.8

During cytostatic therapy 

• The urine pH should be at least 7.0

Directions for use

• When changing the dose, it is advisable to increase or decrease it in steps of half a spoonful only
• Measure urine pH with the enclosed indicator strips
• A test result of 7 or more at midday means that the morning dose was too high. Reduce the next morning dose so that the pH response at next midday will then fall within the correct range. The same applies to other recordings
• If the morning pH is found to be too low (less than 6), this means that too small a dose of the granules was taken on the previous evening. Therefore, the next evening dose should be increased

Potassium sodium hydrogen citrate alkalinises the urine.

Potassium sodium hydrogen citrate is available in several formulations. Please note the list below gives examples of products which are available and is not necessarily comprehensive. The listing of a product does not constitute endorsement of the product by EMGuidance; likewise, failure to list a product does not imply that EMGuidance disapproves of the product. This information is put together on the basis of the National Government's Medicines Price Registry at the time of publication

Granules  

• Uralyt-U (Takeda)