Promethazine/ Dibromopropamidine Isethionate

Registered South African indications:

• First and second degree burns and scalds
• Insect bites and stings

Contraindications

• Hypersensitivity to the active ingredient or any of its excipients
• Prolonged treatment of burned or scalded areas
• Acute vesicular and exudative dermatoses

Cautions

• Pregnancy
• Breastfeeding
• Renal impairment
• Hepatic impairment
• Elderly
• Children (2-6 years)
• Broken skin
• Eczematous skin
• Application to large areas of skin
• No improvement within 3 days of treatment
• Contact with material of clothing or bed linen

Forms avail. in SA and covered in this monograph: cre

First and second degree burns and scalds
Insect bites and stings

• Topical (cre): Apply small quantity to affected area, 8-12hrly as needed

For burns and scalds the cream should be applied directly to the area

Minor lesions and those on exposed parts require no covering, only if necessary for protection

On other parts of the body, gauze dressing and bandages may be used

For solar or other ultraviolet light burns, the cream should  be applied lightly

Paed. forms avail. in SA and covered in this monograph: cre

First and second degree burns and scalds
Insect bites and stings

Younger than 2 years

• Not recommended for use

Between 2-6 years

• Topical (cre): Apply small quantity to affected area, 8-12hrly as needed; Max duration: 5 days

Use with caution

A cream with an emollient base is preferred for use

Older than 6 years

• See adult dosage

Do not mix with any other gel or ointment preparations

For burns and scalds the cream should be applied directly to the area

Minor lesions and those on exposed parts require no covering, only if necessary for protection

On other parts of the body, gauze dressing and bandages may be used

For solar or other ultraviolet light burns, the cream should  be applied lightly

Pregnancy 

• Caution; no information available

Breastfeeding

• Caution; no information available 

Renal Impairment 

• Caution; no information available 

Hepatic Impairment 

• Caution; no information available

Elderly 

• Caution; no information available 

Porphyria Information

• Not yet classified (NC)

Drugs in Sport

• Permitted - No warnings

Central Nervous System Disorders

• Drowsiness

Skin and Subcutaneous Tissue Disorders

• Photosensitivity

Immune, Blood and Lymphatic System Disorders

• Skin sensitisation

None known

None routine

Interference with test results

• Antihistamines may suppress positive skin results and should be stopped several days before the test

Promethazine is a long-acting antihistamine with local analgesic properties.

COMBINATION PREPARATIONS

Promethazine/ Dibromopropamidine Isethionate

Cream (per 100g) 2g/0.15g

• Phenergan (Zentiva) originator

Also available in the following forms: Tablet, syrup and injection.