Sodium Citrate/ Sodium Lauryl Sulphoacetate/ Sorbitol

Registered South African indications:

• Relief of occasional constipation and for use as a bowel cleansing regimen in preparation for X-ray examination and rectoscopy

Registered South African contraindications

• Hypersensitivity to the active ingredients or any of the excipients in this combination product
• Inherited fructose intolerance

South African recommendations

Caution in the following patient groups

• Pregnancy
• Breastfeeding
• Renal impairment
• Severe hepatic impairment
• Elderly

Use in specific conditions

• Sodium citrate/sodium lauryl sulphoacetate/sorbitol should not be used in the presence of abdominal pain, nausea, or vomiting

Duration of use

• This product should not be used for a period longer than one week unless directed by a doctor

Change in bowel habits

• If a sudden change in bowel habits persists for more than 2 weeks, a doctor should be consulted before using the enema

Rectal bleeding and bowel movement failure

• Rectal bleeding or failure to have a bowel movement after use of a laxative may indicate a serious condition. Use should be discontinued and a doctor consulted

Excipient precautions

• Care should be taken when administering preparations containing sorbitol to patients with impaired kidney function or severe liver damage

Forms avail. in SA and covered in this monograph: ene

South African registered indications and dosages

Relief of occasional constipation and for use as a bowel cleansing regimen in preparation for X-ray examination and rectoscopy

Sodium Citrate/ Sodium Lauryl Sulphoacetate 70%/ Sorbitol
90/12.9/893 (mg/ml)

• Rectal (ene): 5ml (contents of one tube), with the nozzle inserted completely into the rectum; Desired effect usually occurs within 5-15mins

Directions for use
Twist and pull the seal off the nozzle. Squeeze the tube slightly so that a drop appears at the tip in order to provide lubrication for easier insertion. In adults insert the nozzle completely into the rectum. Empty the entire contents of the tube into the rectum by squeezing the shoulder of the tube. Withdraw the nozzle whilst keeping the tube completely compressed

Paed. forms avail. in SA and covered in this monograph: ene

South African registered indications and dosages

Relief of occasional constipation and for use as a bowel cleansing regimen in preparation for X-ray examination and rectoscopy

Sodium Citrate/ Sodium Lauryl Sulphoacetate 70%/ Sorbitol
90/12.9/893 (mg/ml)

• Rectal (ene): 5ml (contents of one tube), inserted into the rectum; Desired effect usually occurs within 5-15mins

Directions for use
Twist and pull the seal off the nozzle. Squeeze the tube slightly so that a drop appears at the tip in order to provide lubrication for easier insertion. Note: for children under 3 years of age only half the length of the nozzle should be inserted into the rectum (as indicated on the nozzle). Empty the entire contents of the tube into the rectum by squeezing the shoulder of the tube. Withdraw the nozzle whilst keeping the tube completely compressed

Pregnancy

South African recommendations

• Caution; no information available

Breastfeeding

South African recommendations

• Caution; no information available

Fertility

South African recommendations

• No information available

South African recommendations

• Caution; no dose adjustment recommended
  Care should be taken when administering preparations containing sorbitol to patients with impaired kidney function

South African recommendations

• Mild to moderate: No information available
• Severe: Caution; no dose adjustment recommended
  Care should be taken when administering preparations containing sorbitol to patients with severe liver damage

South African recommendations

• Caution; no information available

Gastrointestinal Disorders

Occasional

• Rectal burning sensation

Immune System Disorders

Frequency not known

• Hypersensitivity (general skin reaction with or without hypotension or respiratory distress)

No information available

None routine

Sodium Citrate/ Sodium Lauryl Sulphoacetate/ Sorbitol attracts water into the faecal mass, thus producing a soft motion which may be easily evacuated.

Sodium Citrate/ Sodium Lauryl Sulphoacetate 70%/ Sorbitol

Enema (per ml) 90mg/ 12.9mg/ 893mg

• Microlax Microenema (Johnson & Johnson)